Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus

被引：56

作者：

Li, Yan ^{[1
]}

Stam, Floor J. ^{[2
]}

Aimone, James B. ^{[1
]}

Goulding, Martyn ^{[2
]}

Callaway, Edward M. ^{[3
]}

Gage, Fred H. ^{[1
]}

机构：

[1] Salk Inst Biol Sci, Lab Genet, La Jolla, CA 92037 USA

[2] Salk Inst Biol Sci, Mol Neurobiol Labs, La Jolla, CA 92037 USA

[3] Salk Inst Biol Sci, Syst Neurobiol Labs, La Jolla, CA 92037 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2013年 / 110卷 / 22期

关键词：

adult neurogenesis; interneuron; NEURONAL DIFFERENTIATION; NEUROGENESIS; INTERNEURONS; INTEGRATION; SINGLE; INPUTS;

D O I：

10.1073/pnas.1306912110

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

New neurons, which have been implicated in pattern separation, are continually generated in the dentate gyrus in the adult hippocampus. Using a genetically modified rabies virus, we demonstrated that molecular layer perforant pathway (MOPP) cells innervated newborn granule neurons in adult mouse brain. Stimulating the perforant pathway resulted in the activation of MOPP cells before the activation of dentate granule neurons. Moreover, activation of MOPP cells by focal uncaging of glutamate induced strong inhibition of granule cells. Together, these results indicate that MOPP cells located in the molecular layer of the dentate gyrus contribute to feed-forward inhibition of granule cells via perforant pathway activation.

引用

页码：9106 / 9111

页数：6

共 34 条

[31] Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons [J].