Sorting Out Fate Determination

被引:2
作者
Bakhti, Mostafa [1 ,2 ,3 ]
Bastidas-Ponce, Aimee [1 ,2 ,3 ,4 ]
Lickert, Heiko [1 ,2 ,3 ,4 ]
机构
[1] Helmholtz Zentrum Munchen, Inst Diabet & Regenerat Res, Neuherberg, Germany
[2] Helmholtz Zentrum Munchen, Inst Stem Cell Res, Neuherberg, Germany
[3] German Ctr Diabet Res DZD, Neuherberg, Germany
[4] Tech Univ Munich, Fac Med, Munich, Germany
关键词
D O I
10.1016/j.devcel.2019.03.020
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
How organ morphogenesis specifies cell fate and whether organ progenitors are predetermined or specified via niche signals are critical developmental biology questions. In this issue of Developmental Cell, Nyeng et al. (2019) modulate cell-cell adhesion in the pancreas and provide evidence that progenitors are plastic and instructed by niche signals.
引用
收藏
页码:1 / 3
页数:3
相关论文
共 7 条
  • [1] Modelling the endocrine pancreas in health and disease
    Bakhti, Mostafa
    Boettcher, Anika
    Lickert, Heiko
    [J]. NATURE REVIEWS ENDOCRINOLOGY, 2019, 15 (03) : 155 - 171
  • [2] miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin
    Hamada, Shin
    Satoh, Kennichi
    Miura, Shin
    Hirota, Morihisa
    Kanno, Atsushi
    Masamune, Atsushi
    Kikuta, Kazuhiro
    Kume, Kiyoshi
    Unno, Jun
    Egawa, Shinichi
    Motoi, Fuyuhiko
    Unno, Michiaki
    Shimosegawa, Tooru
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2013, 228 (06) : 1255 - 1263
  • [3] Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis
    Larsen, Hjalte List
    Martin-Coll, Laura
    Nielsen, Alexander Valentin
    Wright, Christopher V. E.
    Trusina, Ala
    Kim, Yung Hae
    Grapin-Botton, Anne
    [J]. NATURE COMMUNICATIONS, 2017, 8
  • [4] EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity
    Lof-Ohlin, Zarah M.
    Nyeng, Pia
    Bechard, Matthew E.
    Hess, Katja
    Bankaitis, Eric
    Greiner, Thomas U.
    Ameri, Jacqueline
    Wright, Christopher V.
    Semb, Henrik
    [J]. NATURE CELL BIOLOGY, 2017, 19 (11) : 1313 - +
  • [5] p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate
    Nyeng, Pia
    Heilmann, Silja
    Lof-Ohlin, Zarah M.
    Pettersson, Nina Fransen
    Hermann, Florian Malte
    Reynolds, Albert B.
    Semb, Henrik
    [J]. DEVELOPMENTAL CELL, 2019, 49 (01) : 31 - +
  • [6] Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development
    Sznurkowska, Magdalena K.
    Hannezo, Edouard
    Azzarelli, Roberta
    Rulands, Steffen
    Nestorowa, Sonia
    Hindley, Christopher J.
    Nichols, Jennifer
    Gottgens, Berthold
    Huch, Meritxell
    Philpott, Anna
    Simons, Benjamin D.
    [J]. DEVELOPMENTAL CELL, 2018, 46 (03) : 360 - +
  • [7] DIRECTED MOVEMENTS AND SELECTIVE ADHESION OF EMBRYONIC AMPHIBIAN CELLS
    TOWNES, PL
    HOLTFRETER, J
    [J]. JOURNAL OF EXPERIMENTAL ZOOLOGY, 1955, 128 (01): : 53 - 120