IL-31: A new key player in dermatology and beyond

被引：112
作者：
Bagci, Isin Sinem [1 ]
Ruzicka, Thomas [1 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Dept Dermatol & Allergol, Frauenlobstr 9-11, D-80337 Munich, Germany
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2018年 / 141卷 / 03期
关键词：
IL-31; receptors; interleukins; cytokines; pruritus; atopic eczema; ONCOSTATIN-M RECEPTOR; CHRONIC SPONTANEOUS URTICARIA; CLIENT-OWNED DOGS; ATOPIC-DERMATITIS; SERUM IL-31; SIGNAL-TRANSDUCTION; INTERLEUKIN; 31; T-CELLS; LOKIVETMAB ZTS-00103289; MONOCLONAL-ANTIBODY;
D O I：
10.1016/j.jaci.2017.10.045
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
IL-31 is a novel cytokine expressed in many human tissues and involved mainly in T(H)2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor a and oncostatin M receptor b. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for directed drug therapy. Regulation of immune responses and cellular differentiation and proliferation are recently elucidated effects of IL-31, suggesting a more complex and diverse area of effect for this novel cytokine. This review summarizes the current knowledge on IL-31 and its receptors and the involvement of IL-31 in diseases both in human subjects and mouse models.
引用
收藏
页码：858 / 866
页数：9
相关论文
共 50 条
  • [31] Distribution of IL-31 and its receptor expressing cells in skin of atopic dermatitis
    Kato, Atsuhiko
    Fujii, Etsuko
    Watanabe, Takeshi
    Takashima, Yoshiaki
    Matsushita, Hiroaki
    Furuhashi, Takuya
    Morita, Akimichi
    JOURNAL OF DERMATOLOGICAL SCIENCE, 2014, 74 (03) : 229 - 235
  • [32] Dendritic Cells Activated by IFN-γ/STAT1 Express IL-31 Receptor and Release Proinflammatory Mediators upon IL-31 Treatment
    Horejs-Hoeck, Jutta
    Schwarz, Harald
    Lamprecht, Sebastian
    Maier, Elisabeth
    Hainzl, Stefan
    Schmittner, Maria
    Posselt, Gernot
    Stoecklinger, Angelika
    Hawranek, Thomas
    Duschl, Albert
    JOURNAL OF IMMUNOLOGY, 2012, 188 (11) : 5319 - 5326
  • [33] The IL-4, IL-13 and IL-31 pathways in atopic dermatitis
    Dubin, Celina
    Del Duca, Ester
    Guttman-Yassky, Emma
    EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2021, 17 (08) : 835 - 852
  • [34] IL-31 Induces Chemotaxis, Calcium Mobilization, Release of Reactive Oxygen Species, and CCL26 in Eosinophils, Which Are Capable to Release IL-31
    Kunsleben, Nikola
    Ruedrich, Urda
    Gehring, Manuela
    Novak, Natalija
    Kapp, Alexander
    Raap, Ulrike
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015, 135 (07) : 1908 - 1911
  • [35] IL-31 and IL-33 circulating levels in allergic contact dermatitis
    Guarneri, F.
    Minciullo, P. L.
    Mannucci, C.
    Calapai, F.
    Saitta, S.
    Cannavo, S. P.
    Gangemi, S.
    EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 47 (05) : 156 - 158
  • [36] IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity
    Takamori, Ayako
    Nambu, Aya
    Sato, Keiko
    Yamaguchi, Sachiko
    Matsuda, Kenshiro
    Numata, Takafumi
    Sugawara, Takeru
    Yoshizaki, Takamichi
    Arae, Ken
    Morita, Hideaki
    Matsumoto, Kenji
    Sudo, Katsuko
    Okumura, Ko
    Kitaura, Jiro
    Matsuda, Hiroshi
    Nakae, Susumu
    SCIENTIFIC REPORTS, 2018, 8
  • [37] Analysis of the IL-31 pathway in Mycosis fungoides and Sezary syndrome
    Moebs, Markus
    Gryzik, Stefanie
    Haidar, Ahmed
    Humme, Daniel
    Beyer, Marc
    Vandersee, Staffan
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 2015, 307 (06) : 479 - 485
  • [38] Increased serum IL-31 levels in chronic spontaneous urticaria and psoriasis with pruritic symptoms
    Chaowattanapanit, Suteeraporn
    Choonhakarn, Charoen
    Salao, Kanin
    Winaikosol, Kengkart
    Julanon, Narachai
    Wongjirattikarn, Rachot
    Foocharoen, Chingching
    Sompornrattanaphan, Mongkhon
    HELIYON, 2020, 6 (12)
  • [39] Divergent in situ expression of IL-31 and IL-31RA between bullous pemphigoid and pemphigus vulgaris
    Ergun, Ecem Zeliha
    Aoki, Rui
    Horvath, Orsolya N.
    Hartmann, Daniela
    Satoh, Takashi K.
    Calabrese, Laura
    Aksu, Ayse Esra Koku
    Gurel, Mehmet Salih
    Manav, Vildan
    Flaig, Michael J.
    Sardy, Miklos
    Ruzicka, Thomas
    French, Lars E.
    Bagci, Isin Sinem
    EXPERIMENTAL DERMATOLOGY, 2023, 32 (09) : 1412 - 1419
  • [40] Serum measurement of interleukin-31 (IL-31) in paediatric atopic dermatitis: elevated levels correlate with severity scoring
    Ezzat, M. H. M.
    Hasan, Z. E.
    Shaheen, K. Y. A.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2011, 25 (03) : 334 - 339
12345