IL-31: A new key player in dermatology and beyond

被引：120

作者：

Bagci, Isin Sinem ^{[1
]}

Ruzicka, Thomas ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Dept Dermatol & Allergol, Frauenlobstr 9-11, D-80337 Munich, Germany

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2018年 / 141卷 / 03期

关键词：

IL-31; receptors; interleukins; cytokines; pruritus; atopic eczema; ONCOSTATIN-M RECEPTOR; CHRONIC SPONTANEOUS URTICARIA; CLIENT-OWNED DOGS; ATOPIC-DERMATITIS; SERUM IL-31; SIGNAL-TRANSDUCTION; INTERLEUKIN; 31; T-CELLS; LOKIVETMAB ZTS-00103289; MONOCLONAL-ANTIBODY;

D O I：

10.1016/j.jaci.2017.10.045

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

IL-31 is a novel cytokine expressed in many human tissues and involved mainly in T(H)2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor a and oncostatin M receptor b. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for directed drug therapy. Regulation of immune responses and cellular differentiation and proliferation are recently elucidated effects of IL-31, suggesting a more complex and diverse area of effect for this novel cytokine. This review summarizes the current knowledge on IL-31 and its receptors and the involvement of IL-31 in diseases both in human subjects and mouse models.

引用

页码：858 / 866

页数：9

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