Pentosidine as a biomarker for microvascular complications in type 2 diabetic patients

被引：59

作者：

Kerkeni, Mohsen ^{[1
]}

Saidi, Amel ^{[1
]}

Bouzidi, Hassan ^{[2
]}

Letaief, Ahmed ^{[3
]}

Ben Yahia, Salim ^{[4
]}

Hammami, Mohamed ^{[1
]}

机构：

[1] Monastir Univ, Higher Inst Biotechnol, Monastir 5000, Tunisia

[2] CHU Tahar Sfar, Dept Biochem, Mahdia, Tunisia

[3] CHU Fattouma Bouguiba, Dept Neurol, Monastir, Tunisia

[4] CHU Fattouma Bouguiba, Dept Ophthalmol, Monastir, Tunisia

来源：

DIABETES & VASCULAR DISEASE RESEARCH | 2013年 / 10卷 / 03期

关键词：

Advanced glycation end product; soluble receptor for advanced glycation end product; pentosidine; diabetic retinopathy; diabetic nephropathy; GLYCATION END-PRODUCTS; VASCULAR COMPLICATIONS; OXIDATIVE STRESS; PLASMA; AGES; ACCUMULATION; RECEPTOR; DISEASE; PATHOPHYSIOLOGY; INFLAMMATION;

D O I：

10.1177/1479164112460253

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serum soluble receptor for advanced glycation end product (sRAGE) may reflect the activity of the advanced glycation end product (AGE)-receptor for advanced glycation end product (RAGE) axis, which has been proposed as a potential mechanism linking hyperglycaemia to vascular complications in diabetes. We have investigated whether serum AGEs, sRAGE and pentosidine levels were increased and correlated with microvascular complications in type 2 diabetes mellitus (DM). We included 30 healthy control subjects, and 200 diabetic patients were divided into two subgroups: 100 patients with diabetic retinopathy and 100 patients with diabetic nephropathy. AGEs, sRAGE and pentosidine were measured in serum by enzyme-linked immunosorbent assay (ELISA). Serum AGEs, sRAGE and pentosidine levels were significantly increased in diabetic patients with retinopathy and in diabetic patients with nephropathy compared to control subjects (p < 0.001). Serum AGEs, sRAGE and pentosidine levels are positively associated with microvascular complications in type 2 DM. Multiple regression analysis reveals serum pentosidine as an independent determinant of the presence of diabetic retinopathy (p = 0.004) and the presence of hypertension (p = 0.018) and hyperlipidaemia (p = 0.036). Pentosidine levels may be a biomarker for microvascular complications in type 2 diabetic patients.

引用

页码：239 / 245

页数：7