Heterodimers and Receptor Mosaics of Different Types of G-Protein-Coupled Receptors

被引：43
作者：
Fuxe, Kjell [1 ]
Marcellino, Daniel [1 ]
Guidolin, Diego [2 ]
Woods, Amina S. [3 ]
Agnati, Luigi F. [4 ,5 ]
机构：
[1] Karolinska Inst, Dept Neurosci, Stockholm, Sweden
[2] Univ Padua, Dept Anat & Physiol, Padua, Italy
[3] DHHS, Natl Inst Drug Abuse, NIH, Baltimore, MD USA
[4] Univ Modena, Dept Biomed Sci, Venice, Italy
[5] IRCCS Lido, Venice, Italy
来源：
PHYSIOLOGY | 2008年 / 23卷 / 06期
关键词：
D O I：
10.1152/physiol.00028.2008
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Through an assembly of interacting GPCRs, heterodimers and high-order heteromers (termed receptor mosaics) are formed and lead to changes in the agonist recognition, signaling, and trafficking of participating receptors via allosteric mechanisms, sometimes involving the appearance of cooperativity. This field has now become a major research area, and this review deals with their physiology being integrators of receptor signaling in the CNS and their use as targets for novel drug development based on their unique pharmacology.
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页码：322 / 332
页数：11
相关论文
共 103 条
[1]  
AGNATI L, J RECEPTOR IN PRESS
[2]   A boolean network modelling of receptor mosaics relevance of topology and cooperativity [J].
Agnati, L. F. ;
Guidolin, D. ;
Leo, G. ;
Fuxe, K. .
JOURNAL OF NEURAL TRANSMISSION, 2007, 114 (01) :77-92
[3]   CHOLECYSTOKININ PEPTIDES INVITRO MODULATE THE CHARACTERISTICS OF THE STRIATAL H-3 N-PROPYLNORAPOMORPHINE SITES [J].
AGNATI, LF ;
CELANI, MF ;
FUXE, K .
ACTA PHYSIOLOGICA SCANDINAVICA, 1983, 118 (01) :79-81
[4]   Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons [J].
Agnati, LF ;
Ferré, S ;
Lluis, C ;
Franco, R ;
Fuxe, K .
PHARMACOLOGICAL REVIEWS, 2003, 55 (03) :509-550
[5]   FAILURE OF NEUROPEPTIDE-Y INVITRO TO INCREASE THE NUMBER OF ALPHA-2-ADRENERGIC BINDING-SITES IN MEMBRANES OF MEDULLA-OBLONGATA OF THE SPONTANEOUS HYPERTENSIVE RAT [J].
AGNATI, LF ;
FUXE, K ;
BENFENATI, F ;
BATTISTINI, N ;
HARFSTRAND, A ;
HOKFELT, T ;
CAVICCHIOLI, L ;
TATEMOTO, K ;
MUTT, V .
ACTA PHYSIOLOGICA SCANDINAVICA, 1983, 119 (03) :309-312
[6]   How proteins come together in the plasma membrane and function in macromolecular assemblies -: Focus on receptor mosaics [J].
Agnati, LF ;
Guidolin, D ;
Genedani, S ;
Ferré, S ;
Bigiani, A ;
Woods, AS ;
Fuxe, K .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2005, 26 (2-3) :133-153
[7]  
Agnati LF, 2002, FROM SYNAPSES TO RULES, P165
[8]  
AGNATI LF, 1980, MED BIOL, V58, P182
[9]  
AGNATI LF, 1982, MED BIOL, V60, P183
[10]   EVIDENCE FOR CHOLECYSTOKININ-DOPAMINE RECEPTOR INTERACTIONS IN THE CENTRAL NERVOUS-SYSTEM OF THE ADULT AND OLD RAT - STUDIES ON THEIR FUNCTIONAL MEANING [J].
AGNATI, LF ;
FUXE, K ;
GIARDINO, L ;
CALZA, L ;
ZOLI, M ;
BATTISTINI, N ;
BENFENATI, F ;
VANDERHAEGHEN, JJ ;
GUIDOLIN, D ;
RUGGERI, M ;
GOLDSTEIN, M .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 448 (JUL) :315-333
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