Investigation of a Lomentospora prolificans case cluster with whole genome sequencing

被引：8

作者：

Boan, Peter ^{[1
,2
]}

Pang, Stanley ^{[3
]}

Gardam, Dianne J. ^{[2
]}

Darragh, Helen ^{[2
]}

Wright, Matthew ^{[1
,2
]}

Coombs, Geoffrey W. ^{[2
,3
]}

机构：

[1] Fiona Stanley Hosp, 11 Robin Warren Ave, Perth, WA 6150, Australia

[2] PathWest Lab Med WA, 11 Robin Warren Ave, Perth, WA 6150, Australia

[3] Murdoch Univ, 90 South St, Perth, WA 6150, Australia

来源：

MEDICAL MYCOLOGY CASE REPORTS | 2020年 / 29卷

关键词：

Lomentospora prolificans; Scedosporium prolificans; Fungal outbreak; Whole genome sequencing; Antifungal resistance; SCEDOSPORIUM; MILTEFOSINE; VORICONAZOLE; COMBINATION; INFECTION; OUTBREAK;

D O I：

10.1016/j.mmcr.2020.05.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Lomentospora prolificans has caused outbreaks in immunocompromised patients. We performed whole genome sequencing (WGS) on 4 L. prolificans isolates from infections occurring during an 8-month period in the haematology unit at Hospital 1., and 2 isolates from unrelated infections at Hospital 2., showing a high number of mutational differences (> 10,000 single nucleotide polymorphisms) between L. prolificans isolates from Hospital 1. Novel typing of isolates by WGS did not demonstrate a single causative strain.

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页码：1 / 4

页数：4

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