Chemoselective Synthesis of Arylpyridines through Suzuki-Miyaura Cross-Coupling Reactions

被引：11

作者：

Perdomo Rivera, Rodisnel ^{[1
,3
]}

Ehlers, Peter ^{[1
,2
]}

Ohlendorf, Lars ^{[1
]}

Torres Rodriguez, Eugenio ^{[3
]}

Villinger, Alexander ^{[1
]}

Langer, Peter ^{[1
,2
]}

机构：

[1] Univ Rostock, Inst Chem, A Einstein Str 3a, D-18059 Rostock, Germany

[2] Univ Rostock, Leibniz Inst Katalyse eV, A Einstein Str 29a, D-18059 Rostock, Germany

[3] Univ Granma, Study Ctr Appl Chem, Carretera Manzanillo Km 17 1-2, Granma 85100, Cuba

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 08期

关键词：

Cross-coupling; Suzuki-Miyaura reaction; Chemoselectivity; Palladium; Pyridines; HALOGENATED NITROGEN; DERIVATIVES; OXYGEN;

D O I：

10.1002/ejoc.201701718

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Bromo-2,3,5-trichloro-6-iodopyridine has been synthesized for the first time and applied in chemo- and site-selective Suzuki-Miyaura cross-coupling reactions. This novel starting material allows the selective synthesis of pentaarylpyridines with up to four different aryl substituents.

引用

页码：990 / 1003

页数：14

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