Review of MiR-200b and cancer chemosensitivity

被引：83

作者：

Feng, Bing ^{[1
]}

Wang, Rui ^{[1
]}

Chen, Long-Bang ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Oncol, Nanjing 210002, Jiangsu, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2012年 / 66卷 / 06期

基金：

中国国家自然科学基金;

关键词：

MiR-200b; Cancer; Chemosensitivity; EPITHELIAL-MESENCHYMAL TRANSITION; MICRORNA EXPRESSION PROFILES; CELL LUNG-CANCER; DOWN-REGULATION; STEM-CELLS; DEVELOPMENTAL REGULATORS; TRANSCRIPTION FACTOR-8; DRUG-RESISTANCE; GENE-EXPRESSION; REPRESSORS ZEB1;

D O I：

10.1016/j.biopha.2012.06.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chemoresistance remains a major obstacle to successful cancer treatment and leads to poor prognosis of the patients, yet the underlying mechanisms have not been fully understood. MicroRNAs (miRNAs) are non-coding small RNAs of 19-22 nucleotides which could negatively regulate gene expressions mainly through 3'-untranslated region (3'UTR) binding of target mRNAs. MiR-200 family (miR-200a, miR-200b, miR-200c, miR-141, and miR-429) is a cluster of miRNAs highly correlated with epithelial-mesenchymal transition (EMT), wherein miR-200b is identified as a critical regulator of tumor invasion, metastasis, and chemosensitivity. Recent advances of miR-200b dysregulation in tumor chemoresistance were summarized. Possible mechanisms and reversion strategies were also addressed. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：397 / 402

页数：6

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