Specific Control of Immunity by Regulatory CD8 T Cells

被引：0
作者：
Tang, Xiaolei [1 ]
Smith, Trevor R. F. [1 ]
Kumar, Vipin [1 ]
机构：
[1] Torrey Pines Inst Mol Studies, Lab Autoimmun, San Diego, CA 92121 USA
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2005年 / 2卷 / 01期
基金：
美国国家卫生研究院;
关键词：
regulatory T cell; Qa-1; TCR-peptides; apoptosis; immune deviation; cross-priming; EAE;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T lymphocytes with dedicated suppressor function (Treg) play a crucial role in the homeostatic control of immunity in the periphery. Several Treg phenotypes have now been identified in the CD4 and CD8 T cell populations, suggesting their down-regulatory function in both human and animal models of autoimmunity, transplantation and tumor immunity. Here we will focus on the CD8 Treg population and their ability to specifically inhibit a pathogenic autoimmune response. This review will detail the current advances in the knowledge of CD8 Treg in the context of antigen specificity, phenotype, MHC restriction, mechanism of action, and priming.
引用
收藏
页码：11 / 19
页数：9
相关论文
共 50 条
  • [41] Human mesenchymal stromal cells enhance the immunomodulatory function of CD8+ CD28- regulatory T cells
    Liu, Qiuli
    Zheng, Haiqing
    Chen, Xiaoyong
    Peng, Yanwen
    Huang, Weijun
    Li, Xiaobo
    Li, Gang
    Xia, Wenjie
    Sun, Qiquan
    Xiang, Andy Peng
    [J]. CELLULAR & MOLECULAR IMMUNOLOGY, 2015, 12 (06) : 708 - 718
  • [42] CD8 T cells promote heart failure progression in mice with preexisting left ventricular dysfunction
    Wang, Dongzhi
    Weng, Xinyu
    Yue, Wenhui
    Shang, Linlin
    Wei, Yidong
    Clemmer, John S.
    Xu, Yawei
    Chen, Yingjie
    [J]. FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [43] B7-H1 Expressed by Activated CD8 T Cells Is Essential for Their Survival
    Pulko, Vesna
    Harris, Kimberley J.
    Liu, Xin
    Gibbons, Rachel M.
    Harrington, Susan M.
    Krco, Christopher J.
    Kwon, Eugene D.
    Dong, Haidong
    [J]. JOURNAL OF IMMUNOLOGY, 2011, 187 (11) : 5606 - 5614
  • [44] Control of the specificity of T cell-mediated anti-idiotype immunity by natural regulatory T cells
    Max Warncke
    Maike Buchner
    Gudrun Thaller
    Anna Dodero
    Alla Bulashevska
    Dietmar Pfeifer
    Jens Timmer
    Hendrik Veelken
    [J]. Cancer Immunology, Immunotherapy, 2011, 60 : 49 - 60
  • [45] Control of the specificity of T cell-mediated anti-idiotype immunity by natural regulatory T cells
    Warncke, Max
    Buchner, Maike
    Thaller, Gudrun
    Dodero, Anna
    Bulashevska, Alla
    Pfeifer, Dietmar
    Timmer, Jens
    Veelken, Hendrik
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2011, 60 (01) : 49 - 60
  • [46] Differential induction of helper and killer T cells from isolated CD4(+)CD8(+) thymocytes in suspension culture
    Iwata, M
    Kuwata, T
    Mukai, M
    Tozawa, Y
    Yokoyama, M
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (09) : 2081 - 2086
  • [47] IL-10 inducible CD8+ regulatory T-cells are enriched in patients with multiple myeloma and impact the generation of antigen-specific T-cells
    Plaumann, Julian
    Engelhardt, Melanie
    Awwad, Mohamed H. S.
    Echchannaoui, Hakim
    Amman, Eva
    Raab, Marc S.
    Hillengass, Jens
    Halama, Niels
    Neuber, Brigitte
    Mueller-Tidow, Carsten
    Goldschmidt, Hartmut
    Hundemer, Michael
    [J]. CANCER IMMUNOLOGY IMMUNOTHERAPY, 2018, 67 (11) : 1695 - 1707
  • [48] Protective low-avidity anti-tumour CD8+T cells are selectively attenuated by regulatory T cells
    Sugiyarto, Gessa
    Prossor, David
    Dadas, Osman
    Arcia-Anaya, E. David
    Elliott, Tim
    James, Edward
    [J]. IMMUNOTHERAPY ADVANCES, 2021, 1 (01):
  • [49] Human CD8 T cells are susceptible to TNF-mediated activation-induced cell death
    Otano, Itziar
    Alvarez, Maite
    Minute, Luna
    Carmen Ochoa, Maria
    Migueliz, Itziar
    Molina, Carmen
    Azpilikueta, Arantza
    de Andrea, Carlos E.
    Etxeberria, Inaki
    Sanmamed, Miguel F.
    Teijeira, Alvaro
    Berraondo, Pedro
    Melero, Ignacio
    [J]. THERANOSTICS, 2020, 10 (10): : 4481 - 4489
  • [50] The ratio of CD8 + lymphocytes to tumor-infiltrating suppressive FOXP3 + effector regulatory T cells is associated with treatment response in invasive breast cancer
    Noriko Goda
    Shinsuke Sasada
    Hideo Shigematsu
    Norio Masumoto
    Koji Arihiro
    Hiroyoshi Nishikawa
    Shimon Sakaguchi
    Morihito Okada
    Takayuki Kadoya
    [J]. Discover Oncology, 13
12345