Specific Control of Immunity by Regulatory CD8 T Cells

被引：0
|
作者：
Tang, Xiaolei [1 ]
Smith, Trevor R. F. [1 ]
Kumar, Vipin [1 ]
机构：
[1] Torrey Pines Inst Mol Studies, Lab Autoimmun, San Diego, CA 92121 USA
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2005年 / 2卷 / 01期
基金：
美国国家卫生研究院;
关键词：
regulatory T cell; Qa-1; TCR-peptides; apoptosis; immune deviation; cross-priming; EAE;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T lymphocytes with dedicated suppressor function (Treg) play a crucial role in the homeostatic control of immunity in the periphery. Several Treg phenotypes have now been identified in the CD4 and CD8 T cell populations, suggesting their down-regulatory function in both human and animal models of autoimmunity, transplantation and tumor immunity. Here we will focus on the CD8 Treg population and their ability to specifically inhibit a pathogenic autoimmune response. This review will detail the current advances in the knowledge of CD8 Treg in the context of antigen specificity, phenotype, MHC restriction, mechanism of action, and priming.
引用
收藏
页码：11 / 19
页数：9
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