The effect of granulocyte and monocyte adsorptive apheresis on serum cytokine levels in patients with ulcerative colitis

被引：21

作者：

Toya, Yosuke ^{[1
]}

Chiba, Toshimi ^{[1
]}

Mizutani, Tomomi ^{[1
]}

Sato, Kunihiko ^{[1
]}

Kasugai, Satoshi ^{[1
]}

Matsuda, Nozomi ^{[1
]}

Orikasa, Shunsuke ^{[1
]}

Shibata, Sho ^{[1
]}

Abiko, Yukito ^{[1
]}

Akasaka, Risaburo ^{[1
]}

Yokoyama, Naoki ^{[1
]}

Oana, Shuhei ^{[1
]}

Hirota, Shigeru ^{[1
]}

Endo, Masaki ^{[1
]}

Suzuki, Kazuyuki ^{[1
]}

机构：

[1] Iwate Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Sch Med, Morioka, Iwate 0208505, Japan

来源：

CYTOKINE | 2013年 / 62卷 / 01期

关键词：

Ulcerative colitis; Granulocyte and monocyte adsorptive apheresis; GMA; Cytokine levels; Interleukin-10; INFLAMMATORY-BOWEL-DISEASE; REFRACTORY CROHNS-DISEASE; POLYMORPHONUCLEAR NEUTROPHILS; SELECTIVE LEUKOCYTAPHERESIS; INTESTINAL INFLAMMATION; INDUCIBLE PROTEIN-10; T-CELLS; ADACOLUMN; EFFICACY; THERAPY;

D O I：

10.1016/j.cyto.2013.01.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Granulocyte and monocyte adsorptive apheresis (GMA) with an Adacolumn has been reported to be effective as induction therapy in ulcerative colitis (UC). However, the effects of GMA on serial changes in cytokine levels have not been well characterized. We therefore, investigated cytokine levels in UC patients before and after treatment with GMA. A total of 16 patients with active UC, 10 men, and six women, mean age, 42.6 years were included. Fourteen patients had total colitis and two patients had left-sided colitis. The study included nine patients with a chronic intermittent course, six with a chronic continuous course and one with a single episode. The duration of each GMA session was 60 min at a flow rate of 30 mL/min as per study protocol. Serum levels of 17 cytokines were determined simultaneously using a Bio-Plex suspension array system before and after treatment with GMA. Serum interleukin (IL)-10 and macrophage inflammatory protein-1 beta levels were increased significantly in UC patients after GMA treatment compared to pre-treatment levels (P < 0.05). In particular, GMA treatment caused a significant increase in serum IL-10 levels compared to pre-treatment in patients with total colitis or with a chronic intermittent UC course. In conclusion, this investigation showed that GMA was associated with a marked increase in serum level of the anti-inflammatory cytokine, IL-10. The rise in circulating IL-10 is interesting, and potentially a significant factor in the efficacy of GMA in patients with inflammatory bowel diseases. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：146 / 150

页数：5

共 30 条

[1] The role of IL-18 in innate immunity [J].