Connectivity-Based Parcellation of the Amygdala Predicts Social Skills in Adolescents with Autism Spectrum Disorder

被引：18
作者：
Rausch, Annika [1 ]
Zhang, Wei [2 ,3 ]
Beckmann, Christian F. [1 ,2 ,4 ]
Buitelaar, Jan K. [1 ,5 ]
Groen, Wouter B. [5 ]
Haak, Koen V. [1 ,2 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr Nijmegen, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, POB 9101, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Ctr Cognit Neuroimaging, NL-6525 EN Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Inst Behav Sci, NL-6525 HR Nijmegen, Netherlands
[4] Univ Oxford, Ctr Funct MRI Brain FMRIB, Oxford OX3 9DU, England
[5] Karakter Child & Adolescent Psychiat Univ Ctr, NL-6500 HB Nijmegen, Netherlands
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2018年 / 48卷 / 02期
基金：
英国惠康基金;
关键词：
Amygdala; Autism spectrum disorder; Functional connectivity; Parcellation; Prefrontal; STATE FUNCTIONAL CONNECTIVITY; BRAIN NETWORKS; FMRI; CORTEX; FLUCTUATIONS; VARIABILITY; STIMULI; MOTION; ADULTS; YOUTH;
D O I：
10.1007/s10803-017-3370-3
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Amygdala dysfunction plays a role in the social impairments in autism spectrum disorders (ASD), but it is unclear which of its subregions are abnormal in ASD. This study compared the volume and functional connectivity (FC) strength of three FC-defined amygdala subregions between ASD and controls, and assessed their relation to social skills in ASD. A subregion associated with the social perception network was enlarged in ASD (F-1 = 7.842, p = .008) and its volume correlated significantly with symptom severity (social skills: r = .548, p = .009). Posthoc analysis revealed that the enlargement was driven by the vmPFC amygdala network. These findings refine our understanding of abnormal amygdala connectivity in ASD and may inform future strategies for therapeutic interventions targeting the amygdalofrontal pathway.
引用
收藏
页码：572 / 582
页数：11
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