Antimicrobial Susceptibility of Stenotrophomonas maltophilia Isolates from Korea, and the Activity of Antimicrobial Combinations against the Isolates

被引：48

作者：

Chung, Hae-Sun ^{[1
,2
]}

Hong, Seong Geun ^{[3
]}

Kim, Young Ree ^{[4
]}

Shin, Kyeong Seob ^{[5
]}

Whang, Dong Hee ^{[6
]}

Ahn, Jee Young ^{[7
]}

Park, Yeon-Joon ^{[8
]}

Uh, Young ^{[9
]}

Chang, Chulhun L. ^{[10
]}

Shin, Jong Hee ^{[11
]}

Lee, Hye Soo ^{[12
]}

Lee, Kyungwon ^{[1
,2
]}

Chong, Yunsop ^{[1
,2
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Lab Med, Seoul, South Korea

[2] Yonsei Univ, Coll Med, Res Inst Antimicrobial Resistance, Seoul, South Korea

[3] CHA Univ, Dept Lab Med, CHA Bundang Med Ctr, Songnam 463712, South Korea

[4] Jeju Natl Univ, Sch Med, Dept Lab Med, Cheju, South Korea

[5] Chungbuk Natl Univ, Coll Med, Dept Lab Med, Cheongju, South Korea

[6] Inje Univ, Coll Med, Dept Lab Med, Seoul, South Korea

[7] Sooncheonhyang Univ, Coll Med, Dept Lab Med, Gumi, South Korea

[8] Catholic Univ Korea, Coll Med, Dept Lab Med, Seoul, South Korea

[9] Yonsei Univ, Wonju Coll Med, Dept Lab Med, Wonju, South Korea

[10] Pusan Natl Univ, Sch Med, Dept Lab Med, Pusan, South Korea

[11] Chonnam Natl Univ, Sch Med, Dept Lab Med, Kwangju, South Korea

[12] Chonbuk Natl Univ, Sch Med, Dept Lab Med, Jeonju, South Korea

来源：

JOURNAL OF KOREAN MEDICAL SCIENCE | 2013年 / 28卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Stenotrophomonas maltophilia; Combination Drug Therapy; Trimethoprim-Sulfamethoxazole; Ticarcillin-Clavulanate; MULTIPLE ANTIBIOTIC-RESISTANCE; IN-VITRO ACTIVITIES; XANTHOMONAS-MALTOPHILIA; SURVEILLANCE PROGRAM; CLINICAL STRAINS; CYSTIC-FIBROSIS; TIGECYCLINE; PATHOGEN; SYNERGY; MULTICENTER;

D O I：

10.3346/jkms.2013.28.1.62

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to determine antimicrobial susceptibility of recent clinical Stenotrophomonas maltophilia isolates from Korea, and to compare the activity levels of several combinations of antimicrobials. A total of 206 non-duplicate clinical isolates of S. maltophilia was collected in 2010 from 11 university hospitals. Antimicrobial susceptibility testing was performed using the Clinical Laboratory Standards Institute agar dilution method. In vitro activity of antimicrobial combinations was tested using the checkerboard method. The susceptibility rates to trimethoprim-sulfamethoxazole and minocycline were 96% and 99%, respectively. The susceptibility rate to levofloxacin was 64%. All of four antimicrobial combinations showed synergy against many S. maltophilia isolates. A combination of trimethoprim-sulfamethoxazole plus ticarcillin-clavulanate was most synergistic among the combinations. None of the combinations showed antagonistic activity. Therefore, some of the combinations may be more useful than individual drugs in the treatment of S. maltophilia infection. Further clinical studies are warranted to validate our in vitro test results.

引用

页码：62 / 66

页数：5

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