Somatostatin as a regulator of first-trimester human trophoblast functions

被引：4

作者：

Biondi, C. ^{[1
]}

Ferretti, M. E. ^{[1
]}

Lunghi, L. ^{[1
]}

Medici, S. ^{[1
]}

Cervellati, F. ^{[1
]}

Abelli, L. ^{[2
]}

Bertoni, F. ^{[2
]}

Adinolfi, E. ^{[3
]}

Vesce, F. ^{[4
]}

Bartolini, G. ^{[5
]}

Papi, A. ^{[5
]}

D'Andrea, S. ^{[6
]}

Berton, S. ^{[6
]}

Baldassarre, G. ^{[6
]}

机构：

[1] Univ Ferrara, Sect Gen Physiol, Dept Biol & Evolut, I-44100 Ferrara, Italy

[2] Univ Ferrara, Sect Comparat Anat, Dept Biol & Evolut, I-44100 Ferrara, Italy

[3] Univ Ferrara, Sect Gen Pathol, Dept Expt & Diagnost Med, I-44100 Ferrara, Italy

[4] Univ Ferrara, Sect Obstet & Gynecol, Dept Biomed Sci & Adv Therapy, I-44100 Ferrara, Italy

[5] Univ Bologna, Dept Evolut Expt Biol, Bologna, Italy

[6] CRO, Div Expt Oncol 2, Aviano, Italy

来源：

PLACENTA | 2008年 / 29卷 / 08期

关键词：

trophoblast-derived cell lines; somatostatin; cyclic AMP; phospholipase A2; cell proliferation migration;

D O I：

10.1016/j.placenta.2008.05.009

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have tested the hypothesis that human early trophoblast is a target for somatostatin (SRIF) regulatory actions. We report for the first time that SSTR2A and 2B transcripts and proteins are present in first-trimester human chorionic villi and the trophoblast-derived HTR-8/SVneo and JAR cells. In both cell lines, SSTR are functional since SRIF inhibits cyclic AMP pathway, Stimulates arachidonic acid release and enhances cell proliferation. Moreover. in HTR-8/SVneo cells, considered a good model of first-trimester EVT SRIF also enhances migration. An involvement of the cyclic AMP pathway in mediating SRIF effects on proliferation and migration is suggested. Our data support the idea that SRIF regulates early trophoblast functions mainly through an interaction with SSTR2. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：660 / 670

页数：11

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