Disseminated intravascular coagulation in sepsis

被引:27
|
作者
Hardaway, RM
Williams, CH
Vasquez, Y
机构
[1] Texas Tech Univ, Hlth Sci Ctr, Dept Surg, El Paso, TX 79905 USA
[2] Texas Tech Univ, Hlth Sci Ctr, Dept Surg & Anesthesiol, El Paso, TX 79905 USA
来源
SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2001年 / 27卷 / 06期
关键词
sepsis; septic shock; disseminated intravascular coagulation; DIC; plasminogen activator;
D O I
10.1055/s-2001-18863
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Disseminated intravascular coagulation (DIC) has been considered a rather rare syndrome characterized by severe bleeding. In fact, both of these beliefs are wrong. Bleeding is fairly rare in DIC. The clotting parameters are usually normal unless the DIC is fulminating. It is usually thought that fibrinogen may be low or absent in DIC. However, afibrinogenemia is rare. Fibrinogen is usually high in DIC because of the high rate of fibrinogen manufacture by the liver in response to stress. DIC is very common and most cases are never diagnosed. This is because it has been hard to find fibrin thrombi in autopsy cases and because acute severe bleeding is uncommon. The reason fibrin thrombi are rare may be because they have been lysed by endogenous fibrinolytic enzymes before the autopsy. The appearance of endogenous fibrinolytic response could be a defense mechanism to lyse the microclots of DIC. In fact, this response is often successful. This defense can be aided by the administration of plasminogen activators that will lyse the clots. Heparin has been used for the treatment of DIC but has proved useless and is, in fact, dangerous. This is because heparin will not dissolve clots and may actually promote platelet agglutination. Administration Df plasminogen activators will actually prevent bleeding diathesis.
引用
收藏
页码:577 / 583
页数:7
相关论文
共 50 条
  • [41] Disseminated Intravascular Coagulation in the Neonate
    Van Vooren, Debra M.
    Bradshaw, Wanda T.
    Blake, Stephanie M.
    NEONATAL NETWORK, 2018, 37 (04): : 205 - 211
  • [42] Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation
    D'Amico, Ramona
    Monaco, Francesco
    Siracusa, Rosalba
    Cordaro, Marika
    Fusco, Roberta
    Peritore, Alessio Filippo
    Gugliandolo, Enrico
    Crupi, Rosalia
    Cuzzocrea, Salvatore
    Di Paola, Rosanna
    Impellizzeri, Daniela
    Genovese, Tiziana
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (21)
  • [43] DISSEMINATED INTRAVASCULAR COAGULATION SYNDROMES
    BICK, RL
    KUNKEL, LA
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 1992, 55 (01) : 1 - 26
  • [44] Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation
    Levi, M
    de Jonge, E
    van der Poll, T
    CRITICAL CARE MEDICINE, 2001, 29 (07) : S90 - S94
  • [45] Schistocytes in disseminated intravascular coagulation
    Lesesve, J-F
    Martin, M.
    Banasiak, C.
    Andre-Kerneis, E.
    Bardet, V.
    Lusina, D.
    Kharbach, A.
    Genevieve, F.
    Lecompte, T.
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2014, 36 (04) : 439 - 443
  • [46] Coagulation and fibrinolysis balance in disseminated intravascular coagulation
    Onishi, Tomoko
    Ishihara, Takashi
    Nogami, Keiji
    PEDIATRICS INTERNATIONAL, 2021, 63 (11) : 1311 - 1318
  • [47] A Pathological Clarification of Sepsis-Associated Disseminated Intravascular Coagulation Based on Comprehensive Coagulation and Fibrinolysis Function
    Onishi, Tomoko
    Nogami, Keiji
    Ishihara, Takashi
    Inoue, Satoki
    Kawaguchi, Masahiko
    Nishio, Kenji
    Fukushima, Hidetada
    Kobayashi, Hiroshi
    Amano, Itsuto
    Nishikubo, Toshiya
    Yamasaki, Masaharu
    Kasahara, Masato
    Shima, Midori
    THROMBOSIS AND HAEMOSTASIS, 2020, 120 (09) : 1257 - 1269
  • [48] Plasma Endothelial Glycocalyx Components as a Potential Biomarker for Predicting the Development of Disseminated Intravascular Coagulation in Patients With Sepsis
    Huang, Xiao
    Hu, Haoran
    Sun, Ting
    Zhu, Weiwei
    Tian, Huanhuan
    Hao, Dong
    Wang, Tao
    Wang, Xiaozhi
    JOURNAL OF INTENSIVE CARE MEDICINE, 2021, 36 (11) : 1286 - 1295
  • [49] Prognostic Impact of the International Society on Thrombosis and Hemostasis Disseminated Intravascular Coagulation Score in Sepsis: A Systematic Review
    Frank, Christian Sandberg
    Larsen, Julie Brogaard
    SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2023, 49 (05): : 471 - 487
  • [50] Thrombin-activatable fibrinolysis inhibitor-a inhibitors: Drugs for sepsis or drugs for disseminated intravascular coagulation?
    Dempfle, Carl-Erik
    Borggrefe, Martin
    CRITICAL CARE MEDICINE, 2009, 37 (05) : 1823 - 1824