Estrogen induces elevation of cAMP-dependent protein kinase activity in immortalized hippocampal neurons: imaging in living cells - Rapid communication

被引：13

作者：

Shingo, AS ^{[1
]}

Kito, S ^{[1
]}

机构：

[1] Hyogo Univ, Sch Hlth Sci, Kakogawa, Hyogo 6750101, Japan

来源：

JOURNAL OF NEURAL TRANSMISSION | 2002年 / 109卷 / 02期

关键词：

estradiol; cAMP; PKA; hippocampus;

D O I：

10.1007/s007020200012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

17beta-estradiol-stimulated PKA activation in living differentiated H19-7 cells was visualized using DR2, a cell-permeable fluorescent PKA substrate. Estradiol induced marked changes of fluorescence in cytosolic areas and these were inhibited by a PKA inhibitor.

引用

页码：171 / 174

页数：4

共 11 条

[1] ESTROGEN ACTION VIA THE CAMP SIGNALING PATHWAY - STIMULATION OF ADENYLATE-CYCLASE AND CAMP-REGULATED GENE-TRANSCRIPTION [J].

ARONICA, SM ;

KRAUS, WL ;

KATZENELLENBOGEN, BS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (18) :8517-8521

[2]

BLUMENTHAL DK, 1986, J BIOL CHEM, V261, P8140

[3]

Eves EM, 1996, J NEUROCHEM, V67, P1908

[4] Imaging of cAMP-dependent protein kinase activity in living neural cells using a novel fluorescent substrate [J].

Higashi, H ;

Sato, K ;

Ohtake, A ;

Omori, A ;

Yoshida, S ;

Kudo, Y .

FEBS LETTERS, 1997, 414 (01) :55-60

[5] CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE RESPONSE ELEMENT-BINDING PROTEIN (CREB) AND RELATED TRANSCRIPTION-ACTIVATING DEOXYRIBONUCLEIC ACID-BINDING PROTEINS [J].

MEYER, TE ;

HABENER, JF .

ENDOCRINE REVIEWS, 1993, 14 (03) :269-290

[6] 17-BETA-ESTRADIOL DEPOLARIZATION OF HYPOTHALAMIC NEURONS IS MEDIATED BY CYCLIC-AMP [J].

MINAMI, T ;

OOMURA, Y ;

NABEKURA, J ;

FUKUDA, A .

BRAIN RESEARCH, 1990, 519 (1-2) :301-307

[7] A NEW, NONGENOMIC ESTROGEN ACTION - THE RAPID RELEASE OF INTRACELLULAR CALCIUM [J].

MORLEY, P ;

WHITFIELD, JF ;

VANDERHYDEN, BC ;

TSANG, BK ;

SCHWARTZ, JL .

ENDOCRINOLOGY, 1992, 131 (03) :1305-1312

[8] MECHANISM OF THE RAPID EFFECT OF 17-BETA-ESTRADIOL ON MEDIAL AMYGDALA NEURONS [J].

NABEKURA, J ;

OOMURA, Y ;

MINAMI, T ;

MIZUNO, Y ;

FUKUDA, A .

SCIENCE, 1986, 233 (4760) :226-228

[9]

SHINGO AS, 1999, SOC NEUR ABSTR, V25

[10]

SHINGO AS, 1998, SOC NEUR ABSTR, V24

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