Long-term preservation of cortically dependent visual function in RCS rats by transplantation

被引：168
作者：
Coffey, PJ
Girman, S
Wang, SM
Hetherington, L
Keegan, DJ
Adamson, P
Greenwood, J
Lund, RD [1 ]
机构：
[1] Univ Utah, Moran Eye Ctr, Dept Ophthalmol, Salt Lake City, UT 84132 USA
[2] Univ Sheffield, Dept Psychol, Sheffield S10 2TP, S Yorkshire, England
[3] Univ Coll, Inst Ophthalmol, London EC1V 9EL, England
来源：
NATURE NEUROSCIENCE | 2002年 / 5卷 / 01期
基金：
英国惠康基金;
关键词：
D O I：
10.1038/nn782
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cell transplantation is one way of limiting the progress of retinal degeneration in animal models of blinding diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Here we transplanted a human retinal pigment epithelia] (RPE) cell line into the subretinal space of one such model, the Royal College of Surgeons (RCS) rat, and showed, using head tracking to moving stripes and pattern discrimination in conjunction with single-unit cortical physiology, that cortically mediated vision can be preserved with this treatment.
引用
收藏
页码：53 / 56
页数：4
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