RETRACTED: Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines (Retracted Article)

被引：8
|
作者：
Al-Salahi, Rashad A. [1 ]
Gamal-Eldeen, Amira M. [2 ]
Alanazi, Amer M. [1 ]
Al-Omar, Mohamed A. [1 ]
Marzouk, Mohamed A. [1 ,3 ]
Fouda, Moustafa M. G. [4 ,5 ]
机构：
[1] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, Riyadh 11451, Saudi Arabia
[2] Natl Res Ctr, Chem Nat Prod Grp, Ctr Excellence Adv Sci, Cairo 12622, Egypt
[3] Natl Res Ctr, Canc Biol Grp, Ctr Excellence Adv Sci, Cairo 12622, Egypt
[4] King Saud Univ, Dept Chem, Coll Sci, Petrochem Res Chair, Riyadh 11451, Saudi Arabia
[5] Natl Res Ctr, Text Res Div, Cairo 12622, Egypt
来源：
MOLECULES | 2013年 / 18卷 / 02期
关键词：
1,2,4-triazoloquinazoline; antitumor; Hep-G2; HCT-116; inflammation; INFLAMMATION; DERIVATIVES; CANCER; AGENTS; PHAGOCYTOSIS; MACROPHAGES; CLEARANCE; MECHANISM; POTENT; SERIES;
D O I：
10.3390/molecules18021434
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1-25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 6-8 and 25 are promising multipotent anti-inflammatory agents.
引用
收藏
页码：1434 / 1446
页数：13
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