RETRACTED: Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines (Retracted Article)

被引：8

作者：

Al-Salahi, Rashad A. ^{[1
]}

Gamal-Eldeen, Amira M. ^{[2
]}

Alanazi, Amer M. ^{[1
]}

Al-Omar, Mohamed A. ^{[1
]}

Marzouk, Mohamed A. ^{[1
,3
]}

Fouda, Moustafa M. G. ^{[4
,5
]}

机构：

[1] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, Riyadh 11451, Saudi Arabia

[2] Natl Res Ctr, Chem Nat Prod Grp, Ctr Excellence Adv Sci, Cairo 12622, Egypt

[3] Natl Res Ctr, Canc Biol Grp, Ctr Excellence Adv Sci, Cairo 12622, Egypt

[4] King Saud Univ, Dept Chem, Coll Sci, Petrochem Res Chair, Riyadh 11451, Saudi Arabia

[5] Natl Res Ctr, Text Res Div, Cairo 12622, Egypt

来源：

MOLECULES | 2013年 / 18卷 / 02期

关键词：

1,2,4-triazoloquinazoline; antitumor; Hep-G2; HCT-116; inflammation; INFLAMMATION; DERIVATIVES; CANCER; AGENTS; PHAGOCYTOSIS; MACROPHAGES; CLEARANCE; MECHANISM; POTENT; SERIES;

D O I：

10.3390/molecules18021434

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1-25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 6-8 and 25 are promising multipotent anti-inflammatory agents.

引用

页码：1434 / 1446

页数：13

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