Inflammatory Breast Cancer: What We Know and What We Need to Learn

被引：97

作者：

Yamauchi, Hideko ^{[8
]}

Woodward, Wendy A. ^{[2
,7
]}

Valero, Vicente ^{[1
,7
]}

Alvarez, Ricardo H. ^{[1
,7
]}

Lucci, Anthony ^{[3
,7
]}

Buchholz, Thomas A. ^{[2
,7
]}

Iwamoto, Takayuki ^{[1
]}

Krishnamurthy, Savitri ^{[4
,7
]}

Yang, Wei ^{[5
,7
]}

Reuben, James M. ^{[6
,7
]}

Hortobagyi, Gabriel N. ^{[1
,7
]}

Ueno, Naoto T. ^{[1
,7
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Unit 1354, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Diagnost Radiol, Houston, TX 77030 USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

[7] Univ Texas MD Anderson Canc Ctr, Morgan Welch Inflammatory Breast Canc Res Program, Houston, TX 77030 USA

[8] St Lukes Int Hosp, Dept Breast Surg Oncol, Tokyo, Japan

来源：

ONCOLOGIST | 2012年 / 17卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Inflammatory breast cancer; Systemic therapy; Targeted therapy; E-CADHERIN EXPRESSION; NEOADJUVANT CHEMOTHERAPY; PATHOLOGICAL DEFINITION; CARCINOMA; TRASTUZUMAB; TRIAL; PHENOTYPE; SIGNATURE; RECONSTRUCTION; IDENTIFICATION;

D O I：

10.1634/theoncologist.2012-0039

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose. We review the current status of multidisciplinary care for patients with inflammatory breast cancer (IBC) and discuss what further research is needed to advance the care of patients with this disease. Design. We performed a comprehensive review of the English-language literature on IBC through computerized literature searches. Results. Significant advances in imaging, including digital mammography, high-resolution ultrasonography with Doppler capabilities, magnetic resonance imaging, and positron emission tomography-computed tomography, have improved the diagnosis and staging of IBC. There are currently no established molecular criteria for distinguishing IBC from noninflammatory breast cancer. Such criteria would be helpful for the diagnosis and development of novel targeted therapies. Combinations of neoadjuvant systemic chemotherapy, surgery, and radiation therapy have led to an improved prognosis; however, the overall 5-year survival rate for patients with IBC remains very low (similar to 30%). Sentinel lymph node biopsy and skin-sparing mastectomy are not recommended for patients with IBC. Conclusion. Optimal management of IBC requires close coordination among medical, surgical, and radiation oncologists, as well as radiologists and pathologists. There is a need to identify molecular changes that define the pathogenesis of IBC to enable eradication of IBC with the use of IBC-specific targeted therapies. The Oncologist 2012;17: 891-899

引用

页码：891 / 899

页数：9

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