Emerging treatments for premature ejaculation: focus on dapoxetine

被引:0
作者
Hellstrom, Wayne J. G. [1 ]
机构
[1] Tulane Univ, Sch Med, Dept Urol, Sect Androl, New Orleans, LA 70112 USA
关键词
dapoxetine; discontinuation syndrome; premature ejaculation; selective serotonin reuptake inhibitor; INDUCED SEXUAL DYSFUNCTION; DOUBLE-BLIND; FEMALE PARTNERS; ERECTILE DYSFUNCTION; SS-CREAM; MEN; PAROXETINE; EFFICACY; PE; MULTICENTER;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Premature ejaculation (PE) is a common problem in men worldwide. It has a significant impact on affected men and their partners in terms of self-esteem, dissatisfaction with their sexual relationships, personal distress, and interpersonal difficulty. Psychological therapies may achieve short-term improvements, but there are limited data on the long-term success of these methods. Oral therapy with long-acting selective serotonin reuptake inhibitors (SSRIs) improves intravaginal ejaculatory latency time (IELT), but these agents are designed to be administered daily and may be associated with unwanted sexual side effects and withdrawal symptoms upon abrupt discontinuation. Dapoxetine is a short-acting SSRI that can be taken as needed (prn) by men with PE. It has been studied in five separate multicenter, randomized, double-blind, placebo-controlled trials involving more than 6000 men with PE. In four studies that evaluated IELT as an endpoint (N = 4843), dapoxetine 30 and 60 mg prn achieved statistically significant increases in IELT versus placebo. Dapoxetine also showed statistically significant improvements in perceived control over ejaculation, PE-related personal distress, and other patient-reported outcomes in all five trials. Dapoxetine treatment is generally well-tolerated, with low incidences of discontinuation syndrome, sexual dysfunction, and treatment-emergent mood symptoms. The most common adverse events with dapoxetine included nausea, diarrhea, headache, dizziness, and somnolence.
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页码:37 / 46
页数:10
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