Inflammation, immunity, and vaccines for Helicobacter pylori infection

被引：27
|
作者：
Velin, Dominique [1 ]
Straubinger, Kathrin [2 ]
Gerhard, Markus [2 ,3 ]
机构：
[1] Univ Lausanne Hosp, Dept Med, Serv Gastroenterol & Hepatol, Lausanne, Switzerland
[2] ImevaX GmbH, Munich, Germany
[3] Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, Munich, Germany
来源：
HELICOBACTER | 2016年 / 21卷
关键词：
H; pylori; innate and adaptive immunity; vaccine development; T-CELL; GASTRIC-CANCER; RETINOIC ACID; C57BL/6; MICE; PROTECTION; RESPONSES; ASTHMA; COLONIZATION; MACROPHAGES; PHAGOCYTOSIS;
D O I：
10.1111/hel.12336
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The tight control of the innate and adaptive immune responses in the stomach mucosa during chronic Helicobacter pylori infection is of prime importance for the bacteria to persist and for the host to prevent inflammation-driven diseases. This review summarizes recent data on the roles of innate and adaptive immune responses during H.pylori/host interactions. In addition, the latest preclinical developments of H.pylori vaccines are discussed with a special focus on the clinical trial reported by Zeng etal., who provided evidence that oral vaccination significantly reduces the acquisition of natural H.pylori infection in children.
引用
收藏
页码：26 / 29
页数：4
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