Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging

被引：91

作者：

Xi, Lei ^{[1
]}

Grobmyer, Stephen R. ^{[2
]}

Wu, Lei ^{[3
]}

Chen, Ruimin ^{[4
]}

Zhou, Guangyin ^{[2
]}

Gutwein, Luke G. ^{[2
]}

Sun, Jingjing ^{[3
]}

Liao, Wenjun ^{[3
]}

Zhou, Qifa ^{[4
]}

Xie, Huikai ^{[3
]}

Jiang, Huabei ^{[1
]}

机构：

[1] Univ Florida, Dept Biomed Engn, Gainesville, FL 32611 USA

[2] Univ Florida, Dept Surg, Gainesville, FL 32611 USA

[3] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA

[4] Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA

来源：

OPTICS EXPRESS | 2012年 / 20卷 / 08期

基金：

美国国家科学基金会;

关键词：

POSITIVE SURGICAL MARGINS; SENTINEL LYMPH-NODES; CONSERVING THERAPY; PARTIAL MASTECTOMY; GROSS EXAMINATION; CANCER; MICROSCOPY; MALIGNANCY; ACCURACY; SYSTEM;

D O I：

10.1364/OE.20.008726

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

The use of photoacoustic effect is a promising approach for biomedical imaging in living tissues. Photoacoustic tomography (PAT) has been demonstrated to image breast cancer, brain vasculature, arthritis and seizure focus owing to its rich optical contrast and high resolution in a single imaging modality. Here we report a microelectromechanical systems (MEMS)-based intraoperative PAT (iPAT) technique, and demonstrate its ability to accurately map tumors in three-dimension and to inspect the completeness of tumor resection during surgery in a tumor-bearing mouse model. The MEMS imaging probe is small and has the potential to be conveniently used to guide surgical resection of tumors in the breast. (C) 2012 Optical Society of America

引用

页码：8726 / 8731

页数：6

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