Dietary nitrate does not alter cardiac function, calcium handling proteins, or SERCA activity in the left ventricle of healthy rats

被引：0

作者：

Kirsh, Aleah J. ^{[1
]}

Juracic, Emma S. ^{[2
]}

Petrick, Heather L. ^{[1
]}

Monaco, Cynthia M. F. ^{[1
]}

Barbeau, Pierre-Andre ^{[1
]}

Tupling, A. Russell ^{[2
]}

Holloway, Graham P. ^{[1
]}

机构：

[1] Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON, Canada

[2] Univ Waterloo, Dept Kinesiol, Waterloo, ON, Canada

来源：

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2020年 / 45卷 / 09期

基金：

加拿大自然科学与工程研究理事会;

关键词：

nitrate; heart; calcium; SERCA; diet; cardiac function; SARCOPLASMIC-RETICULUM CA2+-ATPASE; SKELETAL-MUSCLE; PROTECTS;

D O I：

10.1139/apnm-2020-0078

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Dietary nitrate has been shown to increase cytosolic calcium concentrations within the heart, which would necessitate greater calcium sequestration for relaxation. In the present study we demonstrate that while nitrate supplementation reduced blood pressure, calcium-handling protein content, sarco(endo)plasmic reticulum Ca-ATPase 2a (SERCA) enzymatic properties, and left ventricular function were not altered. In addition, nitrite did not alter in vitro SERCA activity. Combined, these data suggest that in healthy rats, dietary nitrate does not increase left ventricle SERCA-related calcium-handling properties. Novelty Dietary nitrate decreases blood pressure but does not alter left ventricular calcium-handling protein content or SERCA activity in healthy rats.

引用

页码：1049 / 1053

页数：5