Relation of IL28B Gene Polymorphism with Biochemical and Histological Features in Hepatitis C Virus-Induced Liver Disease

被引：48

作者：

Agundez, Jose A. ^{[1
]}

Garcia-Martin, Elena ^{[2
]}

Maestro, Maria L. ^{[3
]}

Cuenca, Francisca ^{[4
]}

Martinez, Carmen ^{[1
]}

Ortega, Luis ^{[5
]}

Carballo, Miguel ^{[6
]}

Vidaurreta, Marta ^{[3
]}

Agreda, Marta ^{[4
]}

Diaz-Zelaya, Gabriela ^{[5
]}

Suarez, Avelina ^{[7
]}

Diaz-Rubio, Manuel ^{[8
]}

Ladero, Jose M.

机构：

[1] Univ Extremadura, Dept Pharmacol, Caceres, Spain

[2] Univ Extremadura, Dept Biochem & Mol Biol, Caceres, Spain

[3] Hosp Clin San Carlos, Inst Invest Sanitaria Hosp Clin San Carlos IdISCC, Serv Clin Biochem, Genom Unit, Madrid, Spain

[4] Hosp Clin San Carlos, Inst Invest Sanitaria Hosp Clin San Carlos IdISCC, Serv Gastroenterol, Liver Unit, Madrid, Spain

[5] Hosp Clin San Carlos, Inst Invest Sanitaria Hosp Clin San Carlos IdISCC, Serv Pathol, Madrid, Spain

[6] Hosp Terrassa, Mol Genet Lab, Terrassa, Barcelona, Spain

[7] Hosp Clin San Carlos IdISCC, Serv Clin Microbiol, Madrid, Spain

[8] Univ Complutense, Inst Invest Sanitaria Hosp Clin San Carlos IdISCC, Hosp Clin San Carlos, Dept Med,Sch Med,Liver Unit,Serv Gastreoenterol, E-28040 Madrid, Spain

来源：

PLOS ONE | 2012年 / 7卷 / 05期

关键词：

SUSTAINED VIROLOGICAL RESPONSE; GENOME-WIDE-ASSOCIATION; HEPATOCELLULAR-CARCINOMA; NATURAL-HISTORY; GENOTYPE; FIBROSIS; THERAPY; CLEARANCE; INFLAMMATION; PROGRESSION;

D O I：

10.1371/journal.pone.0037998

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background/Aims: Polymorphism at the IL28B gene may modify the course of hepatitis C virus (HCV) chronic infection. Our aim was to study the influence of IL28B rs12979860 gene polymorphism on the biochemistry and pathology of HCV-induced disease in the clinical course from mild chronic hepatitis C to hepatocellular carcinoma. Methods: We have determined the rs12979860 single nucleotide polymorphism (SNP) upstream IL28B gene in two groups of patients with HCV-induced chronic liver disease: 1) 268 patients (159 men) with biopsy-proven chronic hepatitis C, to analyse its relation with biochemical, virological and histological features; and 2) 134 patients (97 men) with HCV-related hepatocellular carcinoma. The distribution of the analysed SNP in hepatocellular carcinoma patients was compared with that found in untreated chronic hepatitis C patients. All patients were white and most were Spaniards. Results: In multivariate analysis ALT values were higher (P = 0.001) and GGT values were lower (P, 0.001) in chronic hepatitis C patients homozygotes for the major rs12979860C allele as compared with carriers of the mutated rs12979860T allele. Steatosis was more frequent (Odds ratio = 1.764, 95% C.I. 1.053-2.955) and severe (P = 0.026) in carriers of the rs12979860T allele. No relation was found between the analysed SNP and METAVIR scores for necroinflammation and fibrosis, and there were no differences in the distribution of the analysed SNP between hepatocellular carcinoma and untreated chronic hepatitis C patients. Conclusion: The IL28B rs12979860 polymorphism correlates with the biochemical activity and the presence and severity of liver steatosis in chronic hepatitis C.

引用

页数：6

共 51 条

[21] Association of IL28B gene polymorphism with development of hepatocellular carcinoma in Japanese patients with chronic hepatitis C virus infection [J].