Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics

The polymorphism characterized by a varying number of 48 bp repeats (VNTR) in the dopamine D4 receptor (DRD4) gene was examined in 61 obsessive-compulsive disorder (OCD) probands with and without ties. Most of the OCD patients with ties showed at least one copy of the 7-fold variant compared to those affected subjects without ties (91 vs. 48%, respectively, Yates corrected chi(2) = 5.54, P = 0.018), Similarly, a higher number of copies of this common variant were detected in the group of probands displaying ties compared to those OCD's without ties (Yates corrected chi(2) = 4.66, P = 0.03). Our study suggests that the seven-repeat allele of the DRD4 gene could be a factor in the phenotypic variance of ties among OCD individuals. (C) 1997 Elsevier Science Ireland Ltd.