Levodopa does not enhance the effect of low-frequency repetitive transcranial magnetic stimulation in tinnitus treatment

被引：15

作者：

Kleinjung, Tobias ^{[1
]}

Steffens, Thomas ^{[1
]}

Landgrebe, Michael ^{[2
]}

Vielsmeier, Veronika ^{[1
]}

Frank, Elmar ^{[2
]}

Hajak, Goeran ^{[2
]}

Strutz, Juergen ^{[1
]}

Langguth, Berthold ^{[2
]}

机构：

[1] Univ Regensburg, Dept Otorhinolaryngol, D-93053 Regensburg, Germany

[2] Univ Regensburg, Dept Psychiat Psychotherapy & Psychosomat, D-93053 Regensburg, Germany

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2009年 / 140卷 / 01期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL-BLOOD-FLOW; MOTOR CORTEX; PRIMING STIMULATION; PREFRONTAL CORTEX; DOUBLE-BLIND; RTMS; EXCITABILITY; DEPRESSION; DOPAMINE;

D O I：

10.1016/j.otohns.2008.10.007

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

OBJECTIVE: Low-frequency repetitive transcranial magnetic stimulation (rTMS) has shown promise for the treatment of tinnitus. Experimental data from motor cortex stimulation in healthy Subjects indicate that the Suppressing effect of low-frequency rTMS can be enhanced by dopaminergic receptor activation. Here we investigated whether administration of the dopamine precursor levodopa before low-frequency rTMS enhances its efficacy in tinnitus treatment. STUDY DESIGN: Sixteen patients with chronic tinnitus received 100 mg of levodopa before each session of low-frequency rTMS. Results were compared with a matched control group of 16 patients who received the same treatment, but without levodopa. Treatment outcome was assessed with a standardized tinnitus questionnaire. RESULTS: Both stimulation protocols resulted in a significant reduction of tinnitus scores after 10 days of stimulation; however, there was no significant difference between the two groups. CONCLUSION: Our data suggest that 100 mg of levodopa does not enhance the effect of rTMS in the treatment of tinnitus. (C) 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.

引用

页码：92 / 95

页数：4

共 23 条

[11] Boosting focally-induced brain plasticity by dopamine [J].