Levodopa does not enhance the effect of low-frequency repetitive transcranial magnetic stimulation in tinnitus treatment

被引：15
作者：
Kleinjung, Tobias [1 ]
Steffens, Thomas [1 ]
Landgrebe, Michael [2 ]
Vielsmeier, Veronika [1 ]
Frank, Elmar [2 ]
Hajak, Goeran [2 ]
Strutz, Juergen [1 ]
Langguth, Berthold [2 ]
机构：
[1] Univ Regensburg, Dept Otorhinolaryngol, D-93053 Regensburg, Germany
[2] Univ Regensburg, Dept Psychiat Psychotherapy & Psychosomat, D-93053 Regensburg, Germany
来源：
OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2009年 / 140卷 / 01期
关键词：
POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL-BLOOD-FLOW; MOTOR CORTEX; PRIMING STIMULATION; PREFRONTAL CORTEX; DOUBLE-BLIND; RTMS; EXCITABILITY; DEPRESSION; DOPAMINE;
D O I：
10.1016/j.otohns.2008.10.007
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
OBJECTIVE: Low-frequency repetitive transcranial magnetic stimulation (rTMS) has shown promise for the treatment of tinnitus. Experimental data from motor cortex stimulation in healthy Subjects indicate that the Suppressing effect of low-frequency rTMS can be enhanced by dopaminergic receptor activation. Here we investigated whether administration of the dopamine precursor levodopa before low-frequency rTMS enhances its efficacy in tinnitus treatment. STUDY DESIGN: Sixteen patients with chronic tinnitus received 100 mg of levodopa before each session of low-frequency rTMS. Results were compared with a matched control group of 16 patients who received the same treatment, but without levodopa. Treatment outcome was assessed with a standardized tinnitus questionnaire. RESULTS: Both stimulation protocols resulted in a significant reduction of tinnitus scores after 10 days of stimulation; however, there was no significant difference between the two groups. CONCLUSION: Our data suggest that 100 mg of levodopa does not enhance the effect of rTMS in the treatment of tinnitus. (C) 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.
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收藏
页码：92 / 95
页数：4
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