Four new steroidal glycosides from Solanum torvum and their cytotoxic activities

被引：65
作者：
Lu, Yuanyuan [1 ]
Luo, Jianguang [1 ]
Huang, Xuefeng [1 ]
Kong, Lingyi [1 ]
机构：
[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China
来源：
STEROIDS | 2009年 / 74卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Solanum torvum; Solanolactosides A and B; Torvosides M and N; Steroidal saponins; Cytotoxic activity; PLANTS; SAPONINS; FRUITS;
D O I：
10.1016/j.steroids.2008.09.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two novel C-22 steroidal lactone saponins, namely solanolactosides A, B (1, 2) and two new spirostanol glycosides, namely torvosides M, N (3, 4) were isolated from ethanol extract of aerial parts of Solanum torvum. Their structures were characterized as solanolide 6-O-[alpha-L-rhamnopyranosyl-(1 -> 3)-O-beta-D-quinovopyranoside] (1), solanolide 6-O-[beta-D-xylopyranosyl-(1 -> 3)-O-beta-D-quinovopyranoside] (2), yamogenin 3-O-[beta-D-glucopyranosyl-(1 -> 6)-O-beta-D-glucopyranoside] (3) and neochlorogenin 3-O-[beta-D-glucopyranosyl-(1 -> 6)-O-beta-D-glucopyranoside] (4) on the basis of spectroscopic analysis. The cytotoxicities of the saponins (1-4) were evaluated in vitro against a panel of human cancer cell lines, Compounds 3 and 4 showed significant cytotoxic activity with the cell lines. (C) 2008 Elsevier Inc. All rights reserved.
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页码：95 / 101
页数：7
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