Solvent-Free Synthesis and Antibacterial Evaluation of Novel Coumarin Sulfonamides

被引：16
|
作者：
Mostajeran, Neda [1 ]
Arshad, Farzaneh Amin [1 ]
Aliyan, Hamid [1 ,2 ]
Massah, Ahmad Reza [1 ,2 ]
机构：
[1] Islamic Azad Univ, Shahreza Branch, Dept Chem, Esfahan 86145311, Iran
[2] Islamic Azad Univ, Shahreza Branch, Razi Chem Res Ctr, Esfahan 86145311, Iran
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2018年 / 52卷 / 01期
关键词：
coumarin; sulfonamide; solvent-free synthesis; antibacterial; N-ACYLSULFONAMIDES; EFFICIENT; ANTIFUNGAL; DENSITY; AGENTS; DERIVATIVES; CONVENIENT; ACYLATION; EXCHANGE; CATALYST;
D O I：
10.1007/s11094-018-1756-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of new coumarin-6-sulfonamides have been synthesized as potential antibacterial agents. The reaction of coumarin with chlorosulfonic acid was found to yield the corresponding coumarin sulfonyl chloride (1). In the next step, coumarin sulfonyl chloride, was reacted with various amines in the presence of K2CO3 under solvent-free conditions to produce coumarine sulfonamides (2a - 2s) in good to excellent yields. The chemical structures of the products were elucidated by IR, H-1 NMR, and C-13 NMR spectroscopy and elemental analysis. All the synthesized compounds have been screened for their in vitro anti-bacterial activities against Escherichia coli and Staphylococcus aureus bacteria.
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页码：1 / 7
页数：7
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