Cockayne syndrome B protein (CSB) Linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions

被引：30

作者：

Frontini, Mattia ^{[2
]}

Proietti-De-Santis, Luca ^{[1
]}

机构：

[1] Univ Tuscia, Dept ABAC, Lab Mol Cytogenet & Mutagenesis, I-1100 Viterbo, Italy

[2] Univ London Imperial Coll Sci Technol & Med, Fac Med, MRC Clin Sci Ctr, London, England

来源：

CELL CYCLE | 2009年 / 8卷 / 05期

关键词：

CSB; p53; p300; hypoxia; HIF-1; lifespan; cancer; EXCISION-REPAIR; HYPOXIA; TRANSCRIPTION; AGENTS; GENES; MICE;

D O I：

10.4161/cc.8.5.7754

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Our recent data demonstrate that the CSB protein, besides its role in DNA repair, functions also as a master switch factor that can selectively influence the transcription of specific sets of genes, after DNA damage or hypoxia, by influencing the biological functions of p53. It is likely that the CSB protein, by modulating p53 activity after different cellular stresses would re-equilibrate the physiological response towards cell proliferation and survival instead of cell cycle arrest and cell death. Some important implications of these findings are discussed here.

引用

页码：693 / 696

页数：4

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