Neuropathogenesis of Central Nervous System HIV Infection

被引：3
作者：
McGuire, Jennifer L. [1 ]
Goodkin, Karl
Douglas, Steven D. [2 ]
机构：
[1] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Neurol,Div Neurol, Philadelphia, PA 19104 USA
[2] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Allergy & Immunol, Philadelphia, PA 19104 USA
来源：
PSYCHIATRIC ANNALS | 2013年 / 43卷 / 05期
关键词：
HUMAN-IMMUNODEFICIENCY-VIRUS; NEUROCOGNITIVE DISORDER; BRAIN; AIDS; ENCEPHALITIS; DEMENTIA; INJURY;
D O I：
10.3928/00485713-20130503-05
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) are a common and devastating complication of HIV infection, affecting up to 47% of HIV-seropositive individuals in the combination antiretroviral (cART) era.1 Because HAND independently predicts non-central nervous system (CNS) morbidity and overall HIV mortality,2 there is an urgent need to better understand these disorders to develop therapeutic approaches. However, HIV neuropathogenesis, HAND, and its related neuropathology, HIV-encephalitis (HIVE), are complex and incompletely understood. This article describes the current understanding of the basic virology and neuropathogenesis of HIV that contribute to HAND and HIVE.©Shutterstock.
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收藏
页码：212 / 216
页数：5
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