Prostate-Specific Membrane Antigen-Negative MetastasesA Potential Pitfall in Prostate-Specific Membrane Antigen PET

被引：9

作者：

Noto, Benjamin ^{[1
]}

Springe, Katharina Auf Der ^{[2
]}

Huss, Sebastian ^{[3
]}

Allkemper, Thomas ^{[2
]}

Stegger, Lars ^{[1
]}

机构：

[1] Univ Hosp Muenster, Dept Nucl Med, Albert Schweitzer Campus 1,Bldg A1, D-48149 Munster, Germany

[2] Univ Hosp Muenster, Inst Clin Radiol, Munster, Germany

[3] Univ Munster, Gerhard Domagk Inst Pathol, Munster, Germany

来源：

CLINICAL NUCLEAR MEDICINE | 2018年 / 43卷 / 06期

关键词：

metastases; negative; PET; CT; prostate cancer; PSMA; sensitivity; EXPRESSION; PET/MRI; CANCER;

D O I：

10.1097/RLU.0000000000002073

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Ga-68-PSMA-11 PET/CT was performed in a 74-year-old man because of biochemical recurrence of prostate cancer following radiation therapy of the prostate gland 24 months earlier. Besides focal nuclide accumulation in the prostate gland suggestive of local recurrence, PET scan revealed no further pathologic uptake. However, CT showed multiple pulmonic nodules suggestive of metastases. Thoracotomy and pathologic examination revealed the nodules to be prostate cancer metastasis. Furthermore, immunohistochemical staining with PSMA antibodies demonstrated a virtual lack of PSMA expression. This case demonstrates the possibility of PSMA-negative metastases of prostate cancer an important pitfall that should be known to physicians interpreting PSMA PET.

引用

页码：E186 / E188

页数：3

共 12 条

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van Leeuwen, Pim J. ;

Emmett, Louise ;

Ho, Bao ;

Delprado, Warick ;

Ting, Francis ;

Quoc Nguyen ;

Stricker, Phillip D. .

BJU INTERNATIONAL, 2017, 119 (02) :209-215

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