Prostate-Specific Membrane Antigen-Negative MetastasesA Potential Pitfall in Prostate-Specific Membrane Antigen PET

被引：9

作者：

Noto, Benjamin ^{[1
]}

Springe, Katharina Auf Der ^{[2
]}

Huss, Sebastian ^{[3
]}

Allkemper, Thomas ^{[2
]}

Stegger, Lars ^{[1
]}

机构：

[1] Univ Hosp Muenster, Dept Nucl Med, Albert Schweitzer Campus 1,Bldg A1, D-48149 Munster, Germany

[2] Univ Hosp Muenster, Inst Clin Radiol, Munster, Germany

[3] Univ Munster, Gerhard Domagk Inst Pathol, Munster, Germany

来源：

CLINICAL NUCLEAR MEDICINE | 2018年 / 43卷 / 06期

关键词：

metastases; negative; PET; CT; prostate cancer; PSMA; sensitivity; EXPRESSION; PET/MRI; CANCER;

D O I：

10.1097/RLU.0000000000002073

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Ga-68-PSMA-11 PET/CT was performed in a 74-year-old man because of biochemical recurrence of prostate cancer following radiation therapy of the prostate gland 24 months earlier. Besides focal nuclide accumulation in the prostate gland suggestive of local recurrence, PET scan revealed no further pathologic uptake. However, CT showed multiple pulmonic nodules suggestive of metastases. Thoracotomy and pathologic examination revealed the nodules to be prostate cancer metastasis. Furthermore, immunohistochemical staining with PSMA antibodies demonstrated a virtual lack of PSMA expression. This case demonstrates the possibility of PSMA-negative metastases of prostate cancer an important pitfall that should be known to physicians interpreting PSMA PET.

引用

页码：E186 / E188

页数：3

共 12 条

[1]

Bostwick DG, 1998, CANCER-AM CANCER SOC, V82, P2256, DOI 10.1002/(SICI)1097-0142(19980601)82:11<2256::AID-CNCR22>3.0.CO

[2]

2-S

[3] Initial Experience of 68Ga-PSMA PET/CT Imaging in High-risk Prostate Cancer Patients Prior to Radical Prostatectomy [J].

Budaeus, Lars ;

Leyh-Bannurah, Sami-Ramzi ;

Salomon, Georg ;

Michl, Uwe ;

Heinzer, Hans ;

Huland, Hartwig ;

Graefen, Markus ;

Steuber, Thomas ;

Rosenbaum, Clemens .

EUROPEAN UROLOGY, 2016, 69 (03) :393-396

[4] Local recurrence of prostate cancer after radical prostatectomy is at risk to be missed in 68Ga-PSMA-11-PET of PET/CT and PET/MRI: comparison with mpMRI integrated in simultaneous PET/MRI [J].

Freitag, Martin T. ;

Radtke, Jan P. ;

Afshar-Oromieh, Ali ;

Roethke, Matthias C. ;

Hadaschik, Boris A. ;

Gleave, Martin ;

Bonekamp, David ;

Kopka, Klaus ;

Eder, Matthias ;

Heusser, Thorsten ;

Kachelriess, Marc ;

Wieczorek, Kathrin ;

Sachpekidis, Christos ;

Flechsig, Paul ;

Giesel, Frederik ;

Hohenfellner, Markus ;

Haberkorn, Uwe ;

Schlemmer, Heinz-Peter ;

Dimitrakopoulou-Strauss, A. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2017, 44 (05) :776-787

[5] Heterogeneous PSMA expression on circulating tumor cells - a potential basis for stratification and monitoring of PSMA-directed therapies in prostate cancer [J].

Gorges, Tobias M. ;

Riethdorf, Sabine ;

von Ahsen, Oliver ;

Nastaly, Paulina ;

Roeck, Katharina ;

Boede, Marcel ;

Peine, Sven ;

Kuske, Andra ;

Schmid, Elke ;

Kneip, Christoph ;

Koenig, Frank ;

Rudolph, Marion ;

Pantel, Klaus .

ONCOTARGET, 2016, 7 (23) :34930-34941

[6] 68Ga-PSMA 11 ligand PET imaging in patients with biochemical recurrence after radical prostatectomy - diagnostic performance and impact on therapeutic decision-making [J].

Grubmueller, B. ;

Baltzer, P. ;

D'Andrea, D. ;

Korn, S. ;

Haug, A. R. ;

Hacker, M. ;

Grubmueller, K. H. ;

Goldner, G. M. ;

Wadsak, W. ;

Pfaff, S. ;

Babich, J. ;

Seitz, C. ;

Fajkovic, H. ;

Susani, M. ;

Mazal, P. ;

Kramer, G. ;

Shariat, S. F. ;

Hartenbach, Markus .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2018, 45 (02) :235-242

[7] Clinical performance of 68Ga-PSMA-11 PET/MRI for the detection of recurrent prostate cancer following radical prostatectomy [J].

Kranzbuhler, Benedikt ;

Nagel, Hannes ;

Becker, Anton S. ;

Mueller, Julian ;

Huellner, Martin ;

Stolzmann, Paul ;

Muehlematter, Urs ;

Guckenberger, Matthias ;

Kaufmann, Philipp A. ;

Eberli, Daniel ;

Burger, Irene A. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2018, 45 (01) :20-30

[8] Heterogeneity of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Carcinoma with Distant Metastasis [J].

Mannweiler, Sebastian ;

Amersdorfer, Peter ;

Trajanoski, Slave ;

Terrett, Jonathan A. ;

King, David ;

Mehes, Gabor .

PATHOLOGY & ONCOLOGY RESEARCH, 2009, 15 (02) :167-172

[9] Diagnostic Efficacy of 68Gallium-PSMA Positron Emission Tomography Compared to Conventional Imaging for Lymph Node Staging of 130 Consecutive Patients with Intermediate to High Risk Prostate Cancer [J].

Maurer, Tobias ;

Gschwend, Juergen E. ;

Rauscher, Isabel ;

Souvatzoglou, Michael ;

Haller, Bernhard ;

Weirich, Gregor ;

Wester, Hans-Juergen ;

Heck, Matthias ;

Kuebler, Hubert ;

Beer, Ambros J. ;

Schwaiger, Markus ;

Eiber, Matthias .

JOURNAL OF UROLOGY, 2016, 195 (05) :1436-1442

[10] Impact of PET acquisition durations on image quality and lesion detectability in whole-body 68Ga-PSMA PET-MRI [J].

Noto, Benjamin ;

Buether, Florian ;

Springe, Katharina Auf Der ;

Avramovic, Nemanja ;

Heindel, Walter ;

Schaefers, Michael ;

Allkemper, Thomas ;

Stegger, Lars .

EJNMMI RESEARCH, 2017, 7

← 1 2 →