Chemical amplification with encapsulated reagents

被引:54
作者
Chen, J
Körner, S
Craig, SL
Lin, S
Rudkevich, DM
Rebek, J
机构
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Duke Univ, Dept Chem, Durham, NC 27708 USA
[3] Univ Texas, Dept Chem & Biochem, Arlington, TX 76019 USA
关键词
D O I
10.1073/pnas.052706499
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Autocatalysis and chemical amplification are characteristic properties of living systems, and they give rise to behaviors such as increased sensitivity, responsiveness, and self-replication. Here we report a synthetic system in which a unique form of compartmentalization leads to nonlinear, autocatalytic behavior. The compartment is a reversibly formed capsule in which a reagent is sequestered. Reaction products displace the reagent from the capsule into solution and the reaction rate is accelerated. The resulting self-regulation is sensitive to the highly selective molecular recognition properties of the capsule.
引用
收藏
页码:2593 / 2596
页数:4
相关论文
共 25 条
[1]   The rational design of high symmetry coordination clusters [J].
Caulder, DL ;
Raymond, KN .
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1999, (08) :1185-1200
[2]   STUDY OF TEMPLATION AND MOLECULAR ENCAPSULATION USING HIGHLY STABLE AND GUEST-SELECTIVE SELF-ASSEMBLING STRUCTURES [J].
CHAPMAN, RG ;
SHERMAN, JC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (35) :9081-9082
[3]  
CHEN J, 2001, IN PRESS NATURE LOND
[4]   Self-assembling capsules [J].
Conn, MM ;
Rebek, J .
CHEMICAL REVIEWS, 1997, 97 (05) :1647-1668
[5]   REACTIONS OF CARBODIIMIDES .2. REACTIONS OF DICYCLOHEXYLCARBODIIMIDE WITH CARBOXYLIC ACIDS IN PRESENCE OF AMINES AND PHENOLS [J].
DETAR, DF ;
SILVERST.R .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1966, 88 (05) :1020-&
[6]   REACTIONS OF CARBODIIMIDES .I. MECHANISMS OF REACTIONS OF ACETIC ACID WITH DICYCLOHEXYLCARBODIIMIDE [J].
DETAR, DF ;
SILVERST.R .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1966, 88 (05) :1013-&
[7]   Molecular paneling via coordination [J].
Fujita, M ;
Umemoto, K ;
Yoshizawa, M ;
Fujita, N ;
Kusukawa, T ;
Biradha, K .
CHEMICAL COMMUNICATIONS, 2001, (06) :509-518
[8]   Pairwise selection of guests in a cylindrical molecular capsule of nanometre dimensions [J].
Heinz, T ;
Rudkevich, DM ;
Rebek, J .
NATURE, 1998, 394 (6695) :764-766
[9]  
Heinz T, 1999, ANGEW CHEM INT EDIT, V38, P1136, DOI 10.1002/(SICI)1521-3773(19990419)38:8<1136::AID-ANIE1136>3.0.CO
[10]  
2-I