The hispanic landscape of triple negative breast cancer

被引：14

作者：

Zevallos, Alejandra ^{[1
]}

Bravo, Leny ^{[1
]}

Bretel, Denisse ^{[2
]}

Paez, Kevin ^{[3
]}

Infante, Ulises ^{[3
]}

Cardenas, Nadezhda ^{[4
]}

Alvarado, Hober ^{[3
]}

Posada, Ana M. ^{[5
]}

Pinto, Joseph A. ^{[6
]}

机构：

[1] Univ Privada San Juan Bautista, Escuela Med Humana, Lima, Peru

[2] GECOPERU, Grp Estudios Clin Oncol Peruano, Lima, Peru

[3] Univ Nacl San Luis Gonzaga Ica, Fac Ciencias Biol, Ica, Peru

[4] Univ Privada San Juan Bautista, Escuela Med Humana Filial Ica, Ica, Peru

[5] Oncosalud AUNA, Unidad Mama, Lima, Peru

[6] Oncosalud AUNA, Unidad Invest Bas & Traslac, Av Guardia Civil 571, Lima 41, Peru

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2020年 / 155卷

关键词：

Triple-negative breast cancer; Epidemiology; Human development index; Ethnicity; LONG-TERM SURVIVAL; RISK-FACTORS; CLINICOPATHOLOGICAL FEATURES; ESTROGEN-RECEPTOR; CLINICAL CHARACTERISTICS; TUMOR CHARACTERISTICS; SOCIOECONOMIC-FACTORS; NEOADJUVANT THERAPY; MOLECULAR SUBTYPES; PREDICTIVE-VALUE;

D O I：

10.1016/j.critrevonc.2020.103094

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Triple-negative breast cancer (TNBC) is a heterogeneous and complex disease characterized by the absence of immunohistochemical expression of estrogen receptor, progesterone receptor and HER2. These breast tumors present an aggressive biology and offer few opportunities to be treated with targeted therapy resulting in bad disease outcomes. The epidemiology of TNBC is intriguing where the understanding of its biology has progressed quickly. One of the peculiarities of this type of cancer is a high prevalence in Afrodescendants and Hispanic patients compared to Caucasian women. In this review we describe some features of TNBC, focusing in the Hispanic population, such as epidemiological, clinicopathological features and molecular features and the correlation between TNBC prevalence and the human development index.

引用

页数：10

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