Hematopoietic Cell Transplantation Comorbidity Index Predicts Outcomes in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes Receiving CD34+ Selected Grafts for Allogeneic Hematopoietic Cell Transplantation

被引：21

作者：

Barba, Pere ^{[1
,2
]}

Ratan, Ravin ^{[1
,3
]}

Cho, Christina ^{[1
,3
]}

Ceberio, Izaskun ^{[1
,4
]}

Hilden, Patrick

Devlin, Sean M. ^{[5
]}

Maloy, Molly A. ^{[1
]}

Barker, Juliet N. ^{[1
,3
]}

Castro-Malaspina, Hugo ^{[1
,3
]}

Jakubowski, Ann A. ^{[1
,3
]}

Koehne, Guenther ^{[1
,3
]}

Papadopoulos, Esperanza B. ^{[1
,3
]}

Ponce, Doris M. ^{[1
,3
]}

Sauter, Craig ^{[1
,3
]}

Tamari, Roni ^{[1
,3
]}

van den Brink, Marcel R. M. ^{[1
,3
]}

Young, James W. ^{[1
,3
]}

O'Reilly, Richard J. ^{[3
,6
]}

Giralt, Sergio A. ^{[1
,3
]}

Perales, Miguel-Angel ^{[1
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplant Serv, 1275 York Ave,Box 298, New York, NY 10065 USA

[2] Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Dept Hematol, Barcelona, Spain

[3] Weill Cornell Med Coll, Dept Med, New York, NY USA

[4] Hosp Univ Donostia, Dept Hematol, Donostia San Sebastian, Spain

[5] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[6] Mem Sloan Kettering Canc Ctr, Dept Pediat, Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2017年 / 23卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HCT-CI; T cell depletion; Allogeneic hematopoietic cell; transplantation; Comorbidity; VERSUS-HOST-DISEASE; ACUTE MYELOGENOUS LEUKEMIA; 1ST COMPLETE REMISSION; REDUCED-INTENSITY; CLINICAL-TRIALS; HCT-CI; ANTITHYMOCYTE GLOBULIN; UNMODIFIED ALLOGRAFTS; PROTOCOL; 0303; BONE-MARROW;

D O I：

10.1016/j.bbmt.2016.10.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To evaluate the association between the hematopoietic cell transplantation-comorbidity index (HCT-CI) and the recently developed age-adjusted HCT-CI (HCT-Cl/age) and transplant outcomes in the setting of CD34-selected allogeneic HCT, we analyzed a homogeneous population of patients undergoing allogeneic HCT with CD34-selected grafts for acute myeloid leukemia and myelodysplastic syndrome (n = 346). Median HCT-CI and HCT-Cliage scores were 2 (percentile 25 to 75, 1 to 4) and 3 (percentile 25 to 75, 1 to 5), respectively. Higher HCT-CI and HC-Cl/age scores were associated with higher nonrelapse mortality (NRM) and lower overall survival (OS). The HCT-CI distinguished 2 risk groups (0 to 2 versus >= 3), whereas, with the HCT-Cliage, there was a progressive increase in NRM and decrease in OS with increasing scores in all 4 groups (0 versus 1 to.2 versus 3 to 4 versus.5). Higher scores in both models were associated with lower chronic graft-versus-host disease relapse-free survival but not with higher relapse. Both models showed a promising predictive accuracy for NRM (c-=.616 for HO'-CI and c-=.647 for HCT-Cl/age). In conclusion, the HCT-CI and HCT-Cl/age predict transplant outcomes in CD34-selected allo-HCT, including NRM, OS, and chronic graft-versus-host disease relapse free survival and may be used to select appropriate patients for this approach. (C) 2017 American Society for Blood and Marrow Transplantation.

引用

页码：67 / 74

页数：8

共 26 条

[1] Comparison of Two Pretransplant Predictive Models and a Flexible HCT-CI Using Different Cut off Points to Determine Low-, Intermediate-, and High-Risk Groups: The Flexible HCT-CI Is the Best Predictor of NRM and OS in a Population of Patients Undergoing allo-RIC [J].

Barba, Pere ;

Luis Pinana, Jose ;

Martino, Rodrigo ;

Valcarcel, David ;

Amoros, Alex ;

Sureda, Anna ;

Briones, Javier ;

Delgado, Julio ;

Brunet, Salut ;

Sierra, Jorge .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (03) :413-420

[2] Ex Vivo T Cell-Depleted versus Unmodified Allografts in Patients with Acute Myeloid Leukemia in First Complete Remission [J].

Bayraktar, Ulas D. ;

de Lima, Marcos ;

Saliba, Rima M. ;

Maloy, Molly ;

Castro-Malaspina, Hugo R. ;

Chen, Julianne ;

Rondon, Gabriela ;

Chiattone, Alexander ;

Jakubowski, Ann A. ;

Boulad, Farid ;

Kernan, Nancy A. ;

O'Reilly, Richard J. ;

Champlin, Richard E. ;

Giralt, Sergio ;

Andersson, Borje S. ;

Papadopoulos, Esperanza B. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2013, 19 (06) :898-903

[3] Transplantation in remission improves the disease-free survival of patients with advanced myelodysplastic syndromes treated with myeloablative T cell-depleted stem cell transplants from HLA-identical siblings [J].

Castro-Malaspina, Hugo ;

Jabubowski, Ann A. ;

Papadopoulos, Esperanza B. ;

Boulad, Farid ;

Young, James W. ;

Kernan, Nancy A. ;

Perales, Miguel A. ;

Small, Trudy N. ;

Hsu, Katharine ;

Chiu, Michelle ;

Heller, Glenn ;

Collins, Nancy H. ;

Jhanwar, Suresh C. ;

van den Brink, Marcel ;

Nimer, Stephen D. ;

O'Reilly, Richard J. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2008, 14 (04) :458-468

[4] Low Risk of Chronic Graft-versus-Host Disease and Relapse Associated with T Cell-Depleted Peripheral Blood Stem Cell Transplantation for Acute Myelogenous Leukemia in First Remission: Results of the Blood and Marrow Transplant Clinical Trials Network Protocol 0303 [J].

Devine, Steven M. ;

Carter, Shelly ;

Soiffer, Robert J. ;

Pasquini, Marcelo C. ;

Hari, Parameswaran N. ;

Stein, Anthony ;

Lazarus, Hillard M. ;

Linker, Charles ;

Stadtmauer, Edward A. ;

Alyea, Edwin P., III ;

Keever-Taylor, Carolyn A. ;

O'Reilly, Richard J. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2011, 17 (09) :1343-1351

[5] The hematopoietic cell transplantation comorbidity index (HCT-CI) predicts clinical outcomes in lymphoma and myeloma patients after reduced-intensity or non-myeloablative allogeneic stem cell transplantation [J].

Farina, L. ;

Bruno, B. ;

Patriarca, F. ;

Spina, F. ;

Sorasio, R. ;

Morelli, M. ;

Fanin, R. ;

Boccadoro, M. ;

Corradini, P. .

LEUKEMIA, 2009, 23 (06) :1131-1138

[6] T Cell-Depleted Stem Cell Transplantation for Adults with High-Risk Acute Lymphoblastic Leukemia: Long-Term Survival for Patients in First Complete Remission with a Decreased Risk of Graft-versus-Host Disease [J].

Goldberg, Jenna D. ;

Linker, Alex ;

Kuk, Deborah ;

Ratan, Ravin ;

Jurcic, Joseph ;

Barker, Juliet N. ;

Castro-Malaspina, Hugo ;

Giralt, Sergio ;

Hsu, Katharine ;

Jakubowski, Ann A. ;

Jenq, Robert ;

Koehne, Guenther ;

Papadopoulos, Esperanza B. ;

van den Brink, Marcel R. M. ;

Young, James W. ;

Boulad, Farid ;

Kernan, Nancy A. ;

O'Reilly, Richard J. ;

Prockop, Susan E. ;

Yahalom, Joachim ;

Heller, Glenn ;

Perales, Miguel-Angel .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2013, 19 (02) :208-213

[7] Comparison of outcomes at two institutions of patients with ALL receiving ex vivo T-cell-depleted or unmodified allografts [J].

Hobbs, G. S. ;

Hamdi, A. ;

Hilden, P. D. ;

Goldberg, J. D. ;

Poon, M. L. ;

Ledesma, C. ;

Devlin, S. M. ;

Rondon, G. ;

Papadopoulos, E. B. ;

Jakubowski, A. A. ;

O'Reilly, R. J. ;

Champlin, R. E. ;

Giralt, S. ;

Perales, M-A ;

Kebriaei, P. .

BONE MARROW TRANSPLANTATION, 2015, 50 (04) :493-498

[8] National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report [J].

Jagasia, Madan H. ;

Greinix, Hildegard T. ;

Arora, Mukta ;

Williams, Kirsten M. ;

Wolff, Daniel ;

Cowen, Edward W. ;

Palmer, Jeanne ;

Weisdorf, Daniel ;

Treister, Nathaniel S. ;

Cheng, Guang-Shing ;

Kerr, Holly ;

Stratton, Pamela ;

Duarte, Rafael F. ;

McDonald, George B. ;

Inamoto, Yoshihiro ;

Vigorito, Afonso ;

Arai, Sally ;

Datiles, Manuel B. ;

Jacobsohn, David ;

Heller, Theo ;

Kitko, Carrie L. ;

Mitchell, Sandra A. ;

Martin, Paul J. ;

Shulman, Howard ;

Wu, Roy S. ;

Cutler, Corey S. ;

Vogelsang, Georgia B. ;

Lee, Stephanie J. ;

Pavletic, Steven Z. ;

Flowers, Mary E. D. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2015, 21 (03) :389-401

[9] T cell-depleted stem-cell transplantation for adults with hematologic malignancies: sustained engraftment of HLA-matched related donor grafts without the use of antithymocyte globulin [J].

Jakubowski, Ann A. ;

Small, Trudy N. ;

Young, James W. ;

Kernan, Nancy A. ;

Castro-Malaspina, Hugo ;

Hsu, Katherine C. ;

Perales, Miguel-Angel ;

Collins, Nancy ;

Cisek, Christine ;

Chiu, Michelle ;

van den Brink, Marcel R. M. ;

O'Reilly, Richard J. ;

Papadopoulos, Esperanza B. .

BLOOD, 2007, 110 (13) :4552-4559

[10] Characteristics of CliniMACS® System CD34-Enriched T Cell-Depleted Grafts in a Multicenter Trial for Acute Myeloid Leukemia-Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Protocol 0303 [J].

Keever-Taylor, Carolyn A. ;

Devine, Steven M. ;

Soiffer, Robert J. ;

Mendizabal, Adam ;

Carter, Shelly ;

Pasquini, Marcelo C. ;

Hari, Parameswaran N. ;

Stein, Anthony ;

Lazarus, Hillard M. ;

Linker, Charles ;

Goldstein, Steven C. ;

Stadtmauer, Edward A. ;

O'Reilly, Richard J. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2012, 18 (05) :690-697

← 1 2 3 →