Insulin-like Growth Factor-I is Inversely Related to Adiposity in Overweight Latino Children

被引：0

作者：

Toledo-Corral, Claudia M. ^{[1
,2
,3
]}

Roberts, Christian K. ^{[1
,2
,3
]}

Shaibi, Gabriel Q. ^{[4
]}

Lane, Christianne J. ^{[1
,2
,3
]}

Higgins, Paul B. ^{[5
,6
]}

Davis, Jaimie N. ^{[1
,2
,3
]}

Weigensberg, Marc J. ^{[1
,2
,3
]}

Goran, Michael I. ^{[1
,2
,3
]}

机构：

[1] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA

[2] Univ So Calif, Dept Pediat, Los Angeles, CA 90089 USA

[3] Univ So Calif, Dept Physiol & Biophys, Los Angeles, CA 90089 USA

[4] Arizona State Univ, Coll Nursing & Healthcare Innovat, Phoenix, AZ USA

[5] Univ Alabama Birmingham, Dept Nutr Sci, Div Physiol & Metab, Birmingham, AL 35294 USA

[6] Univ Alabama Birmingham, Clin Nutr Res Ctr, Birmingham, AL USA

来源：

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2008年 / 21卷 / 09期

关键词：

IGF; IGFBP-1; IGFBP-3; visceral fat; obesity; children;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of this study was to examine interrelationships between IGF-I, IGF binding proteins (IGFBPs) and adiposity in 178 overweight Hispanic adolescents (11.2 +/- 1.7 yr; body mass index: 28.2 +/- 5.4 kg/m(2)). Immunoradiometric assays were used to measure IGF-I, IGFBP-1 and IGFBP-3. Total fat and lean tissue mass were measured by DEXA and visceral and subcutaneous adipose tissue by MRI. IGF-I and IGFBP-3 remained inversely correlated with total body fat mass (r = -0.52, p <0.001 and r = -0.25, p < 0.01, respectively) after controlling for covariates. IGFBP-1 was inversely correlated to total fat mass (r = -0.55, p <0.001) in simple correlations; however, this relationship was eliminated after controlling for covariates (r = 0.02, p = 0.85). Correlations with visceral and subcutaneous adipose tissue yielded similar results. These results demonstrate that IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children.

引用

页码：855 / 864

页数：10

共 32 条

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