Eukaryote polyphosphate kinases: is the 'Kornberg' complex ubiquitous?

被引：29

作者：

Hooley, Paul ^{[1
]}

Whitehead, Michael P. ^{[1
]}

Brown, Michael R. W. ^{[1
]}

机构：

[1] Wolverhampton Univ, Sch Appl Sci, Wolverhampton WV1 1SB, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2008年 / 33卷 / 12期

关键词：

D O I：

10.1016/j.tibs.2008.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyphosphate (poly P) is a polymer of up to several hundred phosphate residues and is important to a variety of cell processes. The main poly P synthetic enzyme in many bacteria is poly P kinase 1 (PPK1), which until recently had been detected among eukaryotes in some protists only. There is now evidence for the presence in several other eukaryotes of PPK1 homologues and also a second bacteria-type enzyme, PPK2. The latest genome databases reveal that the 'Kornberg' enzyme complex of three actin-related proteins, termed DdPPK2 in Dictyostelium discoideum, might also be ubiquitous in eukaryotes. Owing to the intimate association of poly P synthesis with the formation of structural fibres, this ubiquity indicates a central role for this molecule in the evolution of eukaryotic cells.

引用

页码：577 / 582

页数：6

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