Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase

被引：28

作者：

Avlonitis, Nicolaos ^{[1
,2
]}

Debunne, Manuelle ^{[2
]}

Aslam, Tashfeen ^{[1
]}

McDonald, Neil ^{[2
]}

Haslett, Chris ^{[2
]}

Dhaliwal, Kevin ^{[2
]}

Bradley, Mark ^{[1
]}

机构：

[1] Univ Edinburgh, EaStChem, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

[2] Univ Edinburgh, MRC Ctr Inflammat Res, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 26期

基金：

英国医学研究理事会;

关键词：

CATHEPSIN-G; PROTEINASE-3; ENHANCEMENT;

D O I：

10.1039/c3ob40212f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Human neutrophil elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised that allowed the rapid, highly specific and sensitive analysis of HNE activity over closely related proteases.

引用

页码：4414 / 4418

页数：5

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