Quasielastic light scattering study of amyloid β-protein fibril formation

被引：12
|
作者：
Lomakin, A
Teplow, DB
机构：
[1] MIT, Dept Phys, Cambridge, MA 02139 USA
[2] MIT, Ctr Mat Sci & Engn, Cambridge, MA 02139 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA
来源：
PROTEIN AND PEPTIDE LETTERS | 2006年 / 13卷 / 03期
关键词：
Alzheimer's disease; amyloid beta-protein; aggregation; fibril formation; quasielastic light scattering; regularization; elongation; nucleation;
D O I：
10.2174/092986606775338515
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Quasielastic light scattering spectroscopy (QLS) is an optical method for the determination of diffusion coefficients of particles in solution. Here we discuss the principles of QLS and explain how the distribution of particle sizes can be reconstructed from the measured correlation function of scattered light. Non-invasive observation of the temporal evolution of particle sizes provides a powerful tool for studying protein assembly. We illustrate practical applications of QLS with examples from studies of fibril formation of the amyloid beta-protein.
引用
收藏
页码：247 / 254
页数：8
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