A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge

被引：272

作者：

Wu, Shipo ^{[1
]}

Zhong, Gongxun ^{[2
]}

Zhang, Jun ^{[1
]}

Shuai, Lei ^{[2
]}

Zhang, Zhe ^{[1
]}

Wen, Zhiyuan ^{[2
]}

Wang, Busen ^{[1
]}

Zhao, Zhenghao ^{[1
]}

Song, Xiaohong ^{[1
]}

Chen, Yi ^{[1
]}

Liu, Renqiang ^{[2
]}

Fu, Ling ^{[1
]}

Zhang, Jinlong ^{[1
]}

Guo, Qiang ^{[1
]}

Wang, Chong ^{[2
]}

Yang, Yilong ^{[1
]}

Fang, Ting ^{[1
]}

Lv, Peng ^{[1
]}

Wang, Jinliang ^{[2
]}

Xu, Junjie ^{[1
]}

Li, Jianmin ^{[1
]}

Yu, Changming ^{[1
]}

Hou, Lihua ^{[1
]}

Bu, Zhigao ^{[2
]}

Chen, Wei ^{[1
]}

机构：

[1] Beijing Inst Biotechnol, Beijing, Peoples R China

[2] Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

关键词：

ATTENUATED INFLUENZA VACCINE; DOUBLE-BLIND; HEALTHY-ADULTS; EBOLA VACCINE; SAFETY; IMMUNOGENICITY; EFFICACY; CHILDREN;

D O I：

10.1038/s41467-020-17972-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protects ferrets from wild-type SARS-CoV-2 infection in the upper respiratory tract. This study suggests that the mucosal vaccination may provide a desirable protective efficacy and this delivery mode is worth further investigation in human clinical trials.

引用

页数：7

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