The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer

被引：7
作者：
Parizadeh, Seyed Mostafa [1 ]
Jafarzadeh-Esfehani, Reza [2 ]
Avan, Amir [1 ]
Ghandehari, Maryam [1 ,3 ]
Goldani, Fatemeh [1 ]
Parizadeh, Seyed Mohammadreza [1 ]
机构：
[1] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran
[2] Mashhad Univ Med Sci, Fac Med, Dept Med Genet, Mashhad, Iran
[3] Islamic Azad Univ, Fac Med, Student Res Comm, Mashhad Branch, Mashhad, Iran
来源：
CURRENT PHARMACEUTICAL DESIGN | 2018年 / 24卷 / 39期
关键词：
Gastric cancer; tissue mirna; Helicobacter pylori; normal flora; miRNA; gastric mucosa; HELICOBACTER-PYLORI; CELL PROLIFERATION; ONCOGENIC MIRNAS; DOWN-REGULATION; EXPRESSION; INVASION; IDENTIFICATION; INFECTION; PROMOTES;
D O I：
10.2174/1381612825666190110144254
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Gastric cancer (GC) has a high mortality rate with a poor 5-year survival. Helicobacter pylori (H. pylori) is present as part of the normal flora of stomach. It is found in the gastric mucosa of more than half of the world population. This bacterium is involved in developing H. pylori-induced GC due to the regulation of different micro ribonucleic acid (miRNA or miR). miRNAs are small noncoding RNAs and are recognized as prognostic biomarkers for GC that may control gene expression. miRNAs may function as tumor suppressors, or oncogenes. In this review, we evaluated studies that investigated the ectopic expression of miRNAs in the prognosis of H. pylori positive and negative GC.
引用
收藏
页码：4639 / 4645
页数：7
相关论文
共 50 条
  • [31] Frequency of significant virulence genes in gastric biopsies of Helicobacter pylori-positive patients with gastritis
    Gholamhosseinzadeh, Ebrahim
    Ghalehnoei, Hossein
    Veisari, Arash Kazemi
    Sheidaei, Somayeh
    Goli, Hamid Reza
    AMB EXPRESS, 2023, 13 (01)
  • [32] The interplay between aryl hydrocarbon receptor, H. pylori, tryptophan, and arginine in the pathogenesis of gastric cancer
    Pirzadeh, Marzieh
    Khalili, Nastaran
    Rezaei, Nima
    INTERNATIONAL REVIEWS OF IMMUNOLOGY, 2022, 41 (03) : 299 - 312
  • [33] Higher frequency of cagA EPIYA-C Phosphorylation Sites in H. pylori strains from first-degree relatives of gastric cancer patients
    Queiroz, Dulciene M. M.
    Silva, Cicero I. S. M.
    Goncalves, Maria H. R. B.
    Braga-Neto, Manuel B.
    Fialho, Andrea B. C.
    Fialho, Andre M. N.
    Rocha, Gifone A.
    Rocha, Andreia M. C.
    Batista, Sergio A.
    Guerrant, Richard L.
    Lima, Aldo A. M.
    Braga, Lucia L. B. C.
    BMC GASTROENTEROLOGY, 2012, 12
  • [34] Gastric organoids: Advancing the study of H. pylori pathogenesis and inflammation
    Idowu, Sulaimon
    Bertrand, Paul P.
    Walduck, Anna K.
    HELICOBACTER, 2022, 27 (03)
  • [35] Effect of smoking on gastric histology in Helicobacter pylori-positive gastritis
    Koivisto, Tarmo T.
    Voutilainen, Markku E.
    Farkkila, Martti A.
    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2008, 43 (10) : 1177 - 1183
  • [36] Rare case of Helicobacter pylori-positive multiorgan Ig G4-related disease and gastric cancer
    Min Li
    Qiang Zhou
    Kun Yang
    David R Brigstock
    Lu Zhang
    Ming Xiu
    Li Sun
    Run-Ping Gao
    World Journal of Gastroenterology, 2015, 21 (11) : 3429 - 3434
  • [37] Patients with Helicobacter pylori-positive gastric cancer with human cytomegalovirus infection have a low tendency of advanced lymphatic metastasis in a Chinese population
    Chen, Chao
    Chen, Sian
    Han, Zheng
    Xie, Wangkai
    Zhang, Teming
    Mao, Chenchen
    Zhang, Liang
    Sun, Xiangwei
    Kwok, Terry
    Shen, Xian
    Xue, Xiangyang
    ONCOLOGY LETTERS, 2021, 21 (05)
  • [38] Gastric acid secretory response in Helicobacter pylori-positive patients with duodenal ulcer disease
    Jacobson, K
    Chiba, N
    Chen, Y
    Barrientos, M
    James, C
    Riddell, RH
    Hunt, RH
    CANADIAN JOURNAL OF GASTROENTEROLOGY, 2001, 15 (01): : 29 - 39
  • [39] Effects of eradication therapy on gastric emptying in patients with Helicobacter pylori-positive duodenal ulcers
    Onuk, MD
    Uslu, H
    Varoglu, E
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2001, 29 (03) : 178 - 180
  • [40] Immunotyping of lymphocytes in the gastric mucosa of patients infected by H. pylori in two regions with contrast in the risk of developing gastric cancer
    Eduardo Bravo, Luis
    Jenuer Matta, Andres
    Carolina Zambrano, Diana
    ANDES PEDIATRICA, 2022, 93 (03): : 400 - 409
12345