The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer

被引：7
作者：
Parizadeh, Seyed Mostafa [1 ]
Jafarzadeh-Esfehani, Reza [2 ]
Avan, Amir [1 ]
Ghandehari, Maryam [1 ,3 ]
Goldani, Fatemeh [1 ]
Parizadeh, Seyed Mohammadreza [1 ]
机构：
[1] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran
[2] Mashhad Univ Med Sci, Fac Med, Dept Med Genet, Mashhad, Iran
[3] Islamic Azad Univ, Fac Med, Student Res Comm, Mashhad Branch, Mashhad, Iran
来源：
CURRENT PHARMACEUTICAL DESIGN | 2018年 / 24卷 / 39期
关键词：
Gastric cancer; tissue mirna; Helicobacter pylori; normal flora; miRNA; gastric mucosa; HELICOBACTER-PYLORI; CELL PROLIFERATION; ONCOGENIC MIRNAS; DOWN-REGULATION; EXPRESSION; INVASION; IDENTIFICATION; INFECTION; PROMOTES;
D O I：
10.2174/1381612825666190110144254
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Gastric cancer (GC) has a high mortality rate with a poor 5-year survival. Helicobacter pylori (H. pylori) is present as part of the normal flora of stomach. It is found in the gastric mucosa of more than half of the world population. This bacterium is involved in developing H. pylori-induced GC due to the regulation of different micro ribonucleic acid (miRNA or miR). miRNAs are small noncoding RNAs and are recognized as prognostic biomarkers for GC that may control gene expression. miRNAs may function as tumor suppressors, or oncogenes. In this review, we evaluated studies that investigated the ectopic expression of miRNAs in the prognosis of H. pylori positive and negative GC.
引用
收藏
页码：4639 / 4645
页数：7
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