Prevalence and Antimicrobial Resistance of Bacterial Uropathogens Isolated from Dogs and Cats

被引:22
作者
Aurich, Sophie [1 ]
Prenger-Berninghoff, Ellen [1 ]
Ewers, Christa [1 ]
机构
[1] Justus Liebig Univ Giessen, Inst Hyg & Infect Dis Anim, Fac Vet Med, D-35392 Giessen, Germany
来源
ANTIBIOTICS-BASEL | 2022年 / 11卷 / 12期
关键词
urinary tract infection; prevalence; E; coli; enterococci; staphylococci; guidelines; MDR; nitrofurantoin (NIT); URINARY-TRACT-INFECTIONS; ESCHERICHIA-COLI; VETERINARY PRACTICES; CLINICAL SIGNS; PUBLIC-HEALTH; DISEASE; CANINE; SUSCEPTIBILITY; PATTERNS; POPULATION;
D O I
10.3390/antibiotics11121730
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Bacterial urinary tract infection (UTI) is a common diagnosis in companion animal practice and is one of the leading reasons for antimicrobial prescriptions. We analysed 1862 samples from the urinary tract of dogs and cats, submitted to a veterinary microbiological diagnostic laboratory in 2019 and 2020 in Germany. Susceptibility of 962 uropathogenic isolates to 15 antimicrobials, suggested as first- and second-line treatment options for UTI, was determined according to CLSI recommendations. Bacterial growth of uropathogens was detected in 43.9% of dog and in 38.5% of cat samples. Escherichia (E.) coli was the most frequently isolated pathogen (48.4%), followed by Enterococcus spp. (11.9%) and coagulase-positive staphylococci (CoPS; 11.5%). Females were more likely to exhibit a positive microbiological culture. Regarding first-line antibiotics, 93.4% of the most commonly isolated uropathogenic species were susceptible to the first-line antibiotics amoxicillin/clavulanic acid (AMC) and 87.6% to trimethoprim-sulfamethoxazole (SXT), while 76.1% showed decreased susceptibility to ampicillin (AMP). Multidrug resistance (MDR) was detected in 11.9% of E. coli, 50.4% of enterococci, and 42.7% of CoPS; 90.6% of these isolates were susceptible to nitrofurantoin (NIT). Our data indicate that empiric treatment of UTI with AMC or SXT could be recommended and is preferable to treatment with AMX. NIT should be considered for the treatment of MDR uropathogens.
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页数:26
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