Celecoxib antagonizes the cytotoxic effect of cisplatin in human gastric cancer cells by decreasing intracellular cisplatin accumulation

被引：20

作者：

Chen, Minghui ^{[1
]}

Yu, Le ^{[1
]}

Gu, Chunping ^{[1
]}

Zhong, Desheng ^{[1
]}

Wu, Shuguang ^{[1
]}

Liu, Shuwen ^{[1
]}

机构：

[1] So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

来源：

CANCER LETTERS | 2013年 / 329卷 / 02期

关键词：

Gastric cancer; COX-2; Celecoxib; Cisplatin; SELECTIVE CYCLOOXYGENASE-2 INHIBITOR; OVARIAN-CARCINOMA CELLS; CELLULAR ACCUMULATION; IN-VITRO; CHEMOTHERAPY; VIVO; CHEMOPREVENTION; SENSITIVITY; CARBOPLATIN; RESISTANCE;

D O I：

10.1016/j.canlet.2012.10.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cisplatin is a chemotherapeutic drug widely used for the treatment of gastric cancer. The benefit of including COX-2-selective inhibitors in cisplatin-based regimens on anti-cancer effect remains uncertain. In the present study, celecoxib and SC-236 antagonized cisplatin-induced cytotoxicity and apoptosis, whereas indomethancin and nimesulide exerted no effect, implying a COX-2-independent mechanism. Celecoxib decreased whole-cell cisplatin accumulation and DNA platination, resulting from reduced influx. In addition, combined treatment did not elicit greater antitumor activity than cisplatin or celecoxib monotherapy in vivo in a gastric xenograft model. Therefore, treatment strategies with celecoxib in combination with cisplatin should act cautiously. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：189 / 196

页数：8

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