Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182

被引：13

作者：

Mizuhara, Tsukasa ^{[1
]}

Oishi, Shinya ^{[1
]}

Ohno, Hiroaki ^{[1
]}

Shimura, Kazuya ^{[2
]}

Matsuoka, Masao ^{[2
]}

Fujii, Nobutaka ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[2] Kyoto Univ, Inst Virus Res, Sakyo Ku, Kyoto 6068507, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2013年 / 21卷 / 07期

关键词：

Anti-HIV agents; PD; 404182; Photoaffinity labeling; Pyrimidobenzothiazine; HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C VIRUS; POTENT INHIBITORS; BINDING-SITE; CXCR4; ANTAGONISTS; HIV-1; REPLICATION; CCR5; IDENTIFICATION; ENFUVIRTIDE; DERIVATIVES;

D O I：

10.1016/j.bmc.2013.01.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the mechanism of action of the potent antiviral compound PD 404182, three novel photo-affinity probes equipped with a biotin or alkyne indicator were designed and synthesized based on previous structure-activity relationship studies. These probes retained the potent anti-HIV activity of the original pyrimidobenzothiazine derivatives. In photoaffinity labeling studies using HIV-1-infected H9 cells (H9IIIB), eight potential proteins were observed to bind PD 404182. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2079 / 2087

页数：9

共 7 条

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