VEGF induces angiogenesis in a zebrafish embryo glioma model established by transplantation of human glioma cells

被引：20

作者：

Li, Dong ^{[2
]}

Li, Xiang-Pen ^{[1
]}

Wang, Hong-Xuan ^{[1
]}

Shen, Qing-Yu ^{[1
]}

Li, Xiang-Ping ^{[3
]}

Wen, Lu ^{[2
]}

Qin, Xiu-Jiao ^{[2
]}

Jia, Qiu-Li ^{[2
]}

Kung, Hsiang-Fu ^{[2
,4
,5
,6
]}

Peng, Ying ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Neurol, Guangzhou 510120, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sch Life Sci, Lab Integrated Biosci, Guangzhou 510006, Guangdong, Peoples R China

[3] So Med Univ, Nanfang Hosp, Dept ENT, Guangzhou 510515, Guangdong, Peoples R China

[4] Chinese Univ Hong Kong, Stanley Ho Ctr Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China

[5] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Hong Kong, Peoples R China

[6] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol So China, Guangzhou 510120, Guangdong, Peoples R China

来源：

ONCOLOGY REPORTS | 2012年 / 28卷 / 03期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

zebrafish; glioma model; angiogenesis; VEGF; KDR; ENDOTHELIAL GROWTH-FACTOR; DIFFERENT DEVELOPMENTAL-STAGES; DANIO-RERIO; MALIGNANT GLIOMAS; EXPOSURE ROUTES; CANCER MODEL; IN-VIVO; GLIOBLASTOMA; THERAPY; INHIBITION;

D O I：

10.3892/or.2012.1861

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Zebrafish (Danio rerio) is becoming an increasingly popular vertebrate cancer model. In this study, we established a xenotransplanted zebrafish embryo glioma model to further investigate the molecular mechanisms of tumor angiogenesis. We find that the glioma cell line U87 can survive, proliferate and induce additional SIV branches in zebrafish embryos. In addition, by the means of in situ hybridization and quantitive RT-PCR analyses we find that the transplanted U87 cells can induce the ectopic zebrafish vascular endothelial growth factor A (VEGF A) and its receptor VEGFR2/KDR mRNA expression and increase their expression levels, resulting in additional SIV branches.

引用

页码：937 / 942

页数：6

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