A STATE OF THE ART REVIEW ON SELF EMULSIFYING DRUG DELIVERY SYSTEM

Solubility plays a vital role in achieving the therapeutic efficacy of a drug from a dosage form. Advances in molecular screening techniques for identification of potential drug molecules investigated an increased number of new pharmacologically active lipophilic compounds that are poorly water-soluble about 40% of new chemical entities have been discovered as poorly water-soluble. Numbers of technical strategies have been investigated for improving bioavailability like solid dispersions, cyclodextrins, micronization, surfactants, nanoparticles, lipids, permeation enhancers, etc. It is a great task for a pharmaceutical scientists to formulate oral dosage forms of these drug candidates with sufficient bioavailability. Among the various approaches to improve the oral bioavailability of these drug candidates, self-dispersing lipid formulations is one of the approaches to improve the bioavailability of lipophilic drugs. Self-dispersing lipid formulations is a very broad area that covers self-emulsifying drug delivery system (SEDDS), Self-micro emulsifying drug delivery system (SMEDDS), Self-nano emulsifying drug delivery system (SNEDDS) as carrier systems that have been developed.