Differentiation of malignant tumours from granulomas by using dynamic [18F]-fluoro-L-α-methyltyrosine positron emission tomography

被引:5
作者
Yamaguchi, Aiko [1 ]
Hanaoka, Hirofumi [1 ]
Fujisawa, Yutaka [2 ]
Zhao, Songji [3 ,4 ]
Suzue, Kazutomo [5 ]
Morita, Akihiro [2 ]
Tominaga, Hideyuki [6 ]
Higuchi, Tetsuya [7 ]
Hisaeda, Hajime [5 ]
Tsushima, Yoshito [7 ]
Kuge, Yuji [8 ,9 ]
Iida, Yasuhiko [1 ,2 ]
机构
[1] Gunma Univ, Dept Bioimaging Informat Anal, Grad Sch Med, Maebashi, Gunma 371, Japan
[2] Suzuka Univ Med Sci, Fac Pharmaceut Sci, Suzuka, Mie 5108760, Japan
[3] Hokkaido Univ, Dept Tracer Kinet & Bioanal, Grad Sch Med, Sapporo, Hokkaido, Japan
[4] Hokkaido Univ, Grad Sch Med, Dept Mol Imaging, Sapporo, Hokkaido, Japan
[5] Gunma Univ, Dept Parasitol, Grad Sch Med, Maebashi, Gunma 371, Japan
[6] Fukushima Med Univ, Adv Clin Res Ctr, Fukushima, Japan
[7] Gunma Univ, Dept Diagnost Radiol & Nucl Med, Grad Sch Med, Maebashi, Gunma 371, Japan
[8] Hokkaido Univ, Grad Sch Med, Dept Integrated Mol Imaging, Sapporo, Hokkaido, Japan
[9] Hokkaido Univ, Cent Inst Isotope Sci, Sapporo, Hokkaido, Japan
关键词
3-[F-18]-Fluoro-alpha-methyl-L-tyrosine; Granuloma; Inflammation; Tumour; Dynamic positron emission tomography; F-18-FDG PET; INFLAMMATION; TRANSPORT; DIAGNOSIS; TYROSINE; CANCER; FDG; FET;
D O I
10.1186/s13550-015-0109-z
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Background: Previous clinical studies have revealed the potential of [F-18]-fluoro-L-alpha-methyltyrosine (F-18-FAMT) for the differential diagnosis of malignant tumours from sarcoidosis. However, one concern regarding the differential diagnosis with F-18-FAMT is the possibility of false negatives given the small absolute uptake of F-18-FAMT that has been observed in some malignant tumours. The aim of this study was to evaluate a usefulness of dynamic F-18-FAMT positron emission tomography (PET) for differentiating malignant tumours from granulomas. Methods: Rats bearing both granulomas (Mycobacterium bovis bacillus Calmette-Guerin (BCG)-induced) and tumours (C6 glioma cell-induced) underwent dynamic 2-deoxy-2-[F-18]-fluoro-D-glucose (F-18-FDG) PET and F-18-FAMT PET for 120 min on consecutive days. Time-activity curves, static images, mean standardized uptake values (SUVs) and the SUV ratios (SUVRs; calculated by dividing SUV at each time point by that of 2 min after injection) were assessed. Results: In tumours, F-18-FAMT showed a shoulder peak immediately after the initial distribution followed by gradual clearance compared with granulomas. Although the mean SUV in the tumours (1.00 +/- 0.10) was significantly higher than that in the granulomas (0.88 +/- 0.12), a large overlap was observed. In contrast, the SUVR was markedly higher in tumours than in granulomas (50 min/2 min, 0.72 +/- 0.06 and 0.56 +/- 0.05, respectively) with no overlap. The dynamic patterns, SUVR, and mean SUV of F-18-FDG in the granulomas were comparable to those in the tumours. Conclusions: Dynamic F-18-FAMT and SUVR analysis might compensate for the current limitations and help in improving the diagnostic accuracy of F-18-FAMT.
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页数:8
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